大剂量奥美拉唑对老年胃溃疡合并出血患者再出血的影响研究  

STUDY ON THE INFLUENCE OF HIGH-DOSE OMEPRAZOLE FOR REHEMORRHAGE OF ELDERLY PATIENTS WITH BLEEDING ULCER

作　　者：张秀春[1] 

机构地区：[1]沈阳医学院沈洲医院,沈阳110035

出　　处：《现代预防医学》2011年第12期2430-2431,共2页Modern Preventive Medicine

摘　　要：[目的]探讨大剂量奥美拉唑对老年胃溃疡合并出血患者在再出血的影响。[方法]86例老年胃体溃疡并出血患者分成两组,实验组应用大剂量奥美拉唑持续给药:首次80mg静脉推注,然后以8mg/h的速度持续72h;对照组静脉滴注奥美拉唑每12h1次,每次40mg。应用3d,然后口服奥美拉唑,每日1次,每次20mg,疗程均为1个月,观察两组患者3d和30d再出血率并进行比较。[结果]实验组有3例在3d内再出血,发生率为6.98,而对照组有8例,占18.6,两者比较差异有统计学意义(P﹤0.05)。在30d再出血的情况中,实验组无1例出现,为0,而对照组中有2例出现,占4.65,两者比较差异有统计学意义(P﹤0.05)。[结论]大剂量奥美拉唑治疗在预防老年胃溃疡合并出血患者的近期、远期再出血方面具有积极的治疗作用,可以达到很好的治疗效果,值得在临床广泛应用。[Objective]To explore the influence of high-dose omeprazole for rehemorrhage of elderly patients with bleeding ulcer.[Methods]86 old patients with gastric ulcer and body were divided into two groups.The experimental group were treated with high-dose omeprazole continue：80mg intravenous drug firstly,and then to push note 8mg/h for 72h;The control group was intravenous drip omeprazole every 12 hours,each time for 40mg.It was continued for 3d,and oral omeprazole,1 times/day,and each time was 20mg.All treatment periods were one month.Then we observed the situation of rehemorrhage of the two groups in 3 days and 30 days and compared.[Results]In the experimental group,there were 3 cases bleed again in 3 days,with an incidence of 6.98%,and control group with 8 cases,and accounted for 18.6% with statistically significant between them（P﹤0.05）.On the rehemorrhage of 30th days,no one in experimental group,it was 0%,and 2 patients in the control group,and accounted for 4.65%,with a statistically significant（P﹤0.05）.[Conclusion]The high-dose omeprazole has actively therapy effect in preventing senile paclobutrazol in treatment of patients with bleeding ulcer the short and long term rehemorrhage,can achieve very good therapeutic effect,and it is worth in clinical widely used.

关 键 词：大剂量 奥美拉唑 老年 再出血 

分 类 号：R573.1[医药卫生—消化系统]