人脑胶质瘤中转化生长因子β_2、Smad3蛋白表达及临床意义  

Expressions of Transforming Growth Factor β_2 and Smad3 in Human Gliomas with Different Pathologic Grade Proliferation and Its Clinical Significance

作　　者：苏伟[1] 刘福生[1] 朱贵东[1] 姜中利[2] 金贵善[1] 柴奇[1] 曹泽[1] 

机构地区：[1]首都医科大学北京市神经外科研究所脑肿瘤研究中心,北京市100050 [2]首都医科大学附属北京天坛医院神经外科,北京市100050

出　　处：《中国康复理论与实践》2011年第5期433-436,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：北京市自然科学基金(7102027)

摘　　要：目的探讨人脑胶质瘤组织中转化生长因子β2(TGF-β2)、Smad3蛋白表达水平与患者预后的关系。方法应用免疫组化SP法检测80例人脑胶质瘤组织TGF-β2、Smad3蛋白表达水平,并分析其与患者无进展生存期及总生存期的关系。结果 TGF-β2蛋白和Smad3蛋白在不同级别胶质瘤之间表达具有显著性差异(P<0.05),其表达与病理级别呈正相关(r=0.545,r=0.570,P<0.01)。将所有患者分为TGF-β2或Smad3高表达组和低表达组,其无进展生存期和总生存期均有显著性差异(P0.05)。结论 TGF-β2、Smad3蛋白表达与胶质瘤发生及恶性程度相关;检测两者表达情况可为脑胶质瘤的临床诊治及预后判断提供依据。Objective To investigate the expressions of Transforming Growth Factor β2（TGF-β2） and Smad3 in human gliomas associated with pathologic grading.Methods The expressions of TGFβ2 and Smad3 protein were detected with SP immunhistochemistry in 80 human glioma specimens.The Kapan-Meier survival curves of progression-free survival time and overall survival time in different expression levels was compared with log-rank.Results The expression of TGFβ2 and Smad3 correlated with the pathological grading（r=0.545,r= 0.570,P0.01）.Both progression-free survival time and overall survival time were significantly different between low expression group and high expression group（P ≤ 0.05）.Conclusion Both TGF-β2 and Smad3 correlate well with the occurrence and differentiation of human gliomas,which help for the diagnosis,treatment and prognosis judgment.

关 键 词：脑胶质瘤 转化生长因子β_2 SMAD3 免疫组织化学 

分 类 号：R730.264[医药卫生—肿瘤]