环氧合酶-2在乳腺癌组织中的表达及其临床病理意义  

The expression ofcyciooxygenase-2 in breast cancer tissues and its clinicopathologicai significance

作　　者：韩晖[1] 赵文新[1] 林舜国[1] 许春森[1] 杨映红[2] 郑宇辉[2] 黄建平[2] 

机构地区：[1]福建医科大学附属协和医院普外科,福州350001 [2]福建医科大学附属协和医院病理科,福州350001

出　　处：《中国医师进修杂志》2011年第17期1-3,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的研究环氧合酶-2（COX-2）在乳腺癌组织中的表达及其与临床病理因素之间的关系。方法应用免疫组织化学方法检测60例乳腺癌组织中和20例乳腺正常组织中COX-2的表达情况，并结合临床及病理学资料进行分析。结果COX-2在乳腺癌组织中阳性表达率为65．0％（39／60），在乳腺正常组织中阳性表达率为10．0％（2／20），两者比较差异有统计学意义（P〈0．01）；且COX-2高表达状态与乳腺癌TNM分期、淋巴结转移和肿瘤细胞表皮生长因子受体2（C-erbB-2）表达明显相关（P〈0．05或〈0．01）。结论COX-2在乳腺癌组织中表达显著增高，其表达在乳腺癌的发生、发展中具有重要意义。Objective To investigate the expression of cyclooxygenase-2 （COX-2） in breast cancer tissues,as well as the relationship between COX-2 and the clinicopathological features. Method The expression of COX-2 was detected in 60 cases of breast cancer tissues and 20 cases of breast normal tissues by using immunohistochemistry,and combined with clinicopathological information for analysis. Results The COX-2 expression rate was 65.0%（39/60） in breast cancer tissues and 10.0%（2/20） in breast normal tissues respectively. There was statistic difference between the two （P 〈 0.01 ）. The Over expression of COX-2 was significantly correlated with TNM stages, lymphatic metastasis and the expression of epidermal growuth factor receptor-2 （C-erbB-2） （P 〈 0.05 or 〈 0.01 ）. Conclusion The expression of COX-2 in breast cancer tissues is significantly higher,which might play a fairly important role in tumorigenesis and progression of breast cancer.

关 键 词：环氧水解酶类 乳腺肿瘤 基因表达 

分 类 号：R737.9[医药卫生—肿瘤]