直肠癌癌旁移行粘膜MTS1 基因产物表达的意义  

The expression of MTS1 gene product in transitional mucosa adjacent to rectal carcinomas and its clinical significance

作　　者：苏琪[1] 刘恩卿 陈春生 冯勇 王伟[2] 王之章 

机构地区：[1]海南省人民医院,海口570311 [2]中国医科大学第二临床学院病理科,沈阳110003

出　　处：《中华外科杂志》1999年第8期494-496,共3页Chinese Journal of Surgery

基　　金：辽宁省自然科学基金

摘　　要：目的　探讨直肠癌癌旁移行粘膜（ Ｔ Ｍ） 的性质及多种肿瘤抑制基因（ Ｍ Ｔ Ｓ１） 基因缺失的临床意义。　方法　应用粘液组化方法观察了直肠癌旁 Ｔ Ｍ 的范围，免疫组化方法观察了 Ｍ Ｔ Ｓ１ 基因产物表达情况，并与正常粘膜及癌组织进行对照。　结果　 Ｍ Ｔ Ｓ１ 基因产物在正常直肠粘膜阳性表达率最高，在癌旁 Ｔ Ｍ、癌组织表达逐渐减少，三者差异有显著意义（ Ｐ＜ ００５） ； Ｍ Ｔ Ｓ１ 阴性的直肠癌病例，癌旁 Ｔ Ｍ 的范围明显高于 Ｍ Ｔ Ｓ１ 阳性的病例（ Ｐ＜ ００５） 。　结论　 Ｍ Ｔ Ｓ１ 基因失活与直肠癌的发生有关，癌旁 Ｔ Ｍ 具有一定的恶性潜能。直肠癌旁移行粘膜与直肠癌 Ｍ Ｔ Ｓ１ 表达缺失之间存在一定的相关性，提示 Ｍ Ｔ Ｓ１Objective To study the property of transitional mucosa(TM) adjacent to rectal carcinoma and the clinical significance of MTS1 gene deficit. Methods We used the mucinhistochemical methods to observe the range of TM adjacent to rectal carcinoma, and the immunohistochemical method to observe the expression of MTS1 gene product on TM, using normal mucosa and carcinoma tissue as control. Results The positive expression level of MTS1 gene product was the highest in the normal rectal mucosa, gradually defective in TM and carcinoma tissue ( P <0 05). The range of TM with MTS1 negative cases was prominently larger than that with MTS1 positive cases( P <0 05). Conclusions The inactivation of MTS1 gene is relative to the occurrence of rectal carcinoma, suggesting that the TM adjacent to rectal carcinoma possess as certain potential malignancy. TM is related to MTS1 gene expression deficit of rectal carcinoma, showing that MTS1 gene expression deficit or mutation may be a factor inducing transitional change adjacent to carcinoma.

关 键 词：直肠肿瘤 移行性细胞 TM MTS1基因 

分 类 号：R735.370.2[医药卫生—肿瘤]