PTEN、HER-2在子宫内膜样腺癌组织中的表达及意义  

Expressions and significances of PTEN and HER-2 in endometrioid adenocarcinoma tissues

作　　者：李惠[1] 潘佩英[1] 徐韬[1] 

机构地区：[1]贵州省贵阳市妇幼保健院,550003

出　　处：《中国妇幼保健》2011年第17期2674-2676,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨PTEN、HER-2在子宫内膜样腺癌组织中的表达及意义。方法:运用免疫组织化学技术检测20例增生期子宫内膜、30例子宫内膜增殖症及60例子宫内膜样腺癌组织中PTEN、HER-2的表达。结果:PTEN在增生期子宫内膜、子宫内膜增殖症、子宫内膜样腺癌组织中阳性表达逐渐降低,并且在子宫内膜样腺癌组织中的表达与增生期子宫内膜、子宫内膜增殖症的表达比较差异有统计学意义(P<0.05);在子宫内膜样腺癌组织中PTEN的表达与病理组织学分级、临床分期有关(P<0.05),与肌层浸润及淋巴结转移无关(P>0.05)。HER-2在增生期子宫内膜、子宫内膜增殖症、子宫内膜样腺癌组织中阳性表达呈逐渐增高的趋势,HER-2在子宫内膜样腺癌中的表达与增生期子宫内膜表达比较差异有统计学意义(P<0.05),与子宫内膜增殖症比较差异无统计学意义(P>0.05),将增生期子宫内膜和子宫内膜增殖症合并为一组与子宫内膜样腺癌组比较差异有统计学意义(P<0.05);HER-2在子宫内膜样腺癌中有不同程度的表达,并随着肿瘤病理分级(P<0.01)、肌层浸润深度(P<0.01)、临床分期(P<0.01)的增加及出现淋巴结转移(P<0.05)时表达增强,且差异有统计学意义;子宫内膜样腺癌中PTEN表达与HER-2表达成负相关关系(rs=-1.000,P=0,α=0.01)。结论:PTEN的检测可作为子宫内膜样腺癌早期诊断的标记物,HER-2的检测可作为判断子宫内膜样腺癌预后的指征,PTEN的缺失和HER-2的过表达在子宫内膜样腺癌的发生、发展中具有一定意义。Objective： To explore the expressions and significances of PTEN and HER - 2 in endometrioid adenocarcinoma tissues. Methods ： Immunohistochemical technique was used to detect the expression levels of FFEN and HER - 2 in 20 cases with endometrium tissues in proliferative stage, 30 cases with endometrial hyperplasia tissues and 60 cases with endometrioid adenocarcinoma tissues. Results： The positive expression rate of PTEN decreased gradually from endometrium tissues in proliferative stage, endometrial hyperplasia tissues to endometrioid adenocarcinoma tissues, and there was significant difference in positive expression rate of PTEN between endometrioid adenocarcinoma tissues and endometrium tissues in proliferative stage, endometrial hyperplasia tissues （ P 〈 0.05 ） ; in endometrioid adenocarcinoma tissues, PTEN expression was related to histopathological grades and clinical stages （ P 〈 0.05 ）, there was no correlation between PTEN expression and lymph node metastasis （ P 〉 0. 05 ） . The positive expression rate of HER - 2 increased gradually from endometrium tissues in proliferative stage, endometrial hyperplasia tissues to endoinetrioid adenocarcinoma tissues, and there was significant difference in positive expression rate of HER - 2 between endometrioid adenocarcinoma tissues and endometrium tissues in proliferative stage （ P 〈 0. 05 ） , there was no significant difference in positive expression rate of HER - 2 between endometrioid adenocarcinoma tissues and endometrial hyperplasia tissues （ P 〉 0. 05 ） , there was significant difference between endometrioid adenocarcinoma tissues and a combined group consisted of endometrium tissues in proliferative stage and endometrial hyperplasia tissues （ P 〈 0. 05 ） ; HER - 2 expressed in endometrioid adenocarcinoma tissues at different levels, increasing with pathological grades （P 〈 0. 01 ）, depth of myometrial invasion （P 〈 0. 01 ）, clinical stages （P 〈 0. 01 ） and lymph node metastasis （P 〈 0. 05 ）, a

关 键 词：子宫内膜肿瘤 PTEN HER-2 

分 类 号：R737.3[医药卫生—肿瘤]