血管内皮生长因子表达和微血管密度与多形性腺瘤临床病理类型关系的研究  

Study on the relationships among expression of vasculare endothelial growth factor、microvessel density and clinicopathological characters of pleomorphic adenoma

作　　者：兰海松[1] 滕英[1] 李艺芳[1] 

机构地区：[1]广东省肇庆市第一人民医院口腔科,526000

出　　处：《齐齐哈尔医学院学报》2011年第8期1211-1212,共2页Journal of Qiqihar Medical University

摘　　要：目的探讨血管内皮生长因子(VEGF)的表达和微血管密度(MVD)与多形性腺瘤(PA)临床病理类型的关系。方法选取2000年6月～2010年8月肇庆市第一人民医院手术切除、病理科保存的涎腺肿瘤石蜡包埋组织标本,包括正常涎腺组织30例、PA65例(35例原发、30例复发),应用免疫组化SP法检测其中VEGF的表达和MVD。结果 VEGF的阳性表达率和MVD计数在正常唾液腺组织、原发PA、复发PA中依次增加,组间差异均具有统计学意义(P<0.05);PA中MVD计数随着VEGF表达的增强而升高(P<0.05)。结论 VEGF的表达和MVD与MEC的临床病理类型密切相关。Objective To explore the relationships among expression of vasculare endothelial growth factor（VEGF）, microvessel density（MVD）and clinicopathological characters of pleomorphic adenoma（PA）. Methods SP immunochemistry was applied to detect the expression of VEGF;microvessel density was counted by anti--CD34 antibody in 30 cases of normal salivary tissues,35 cases of primary PA tissue,30 cases of recurrent PA tissues. Results Positive expression rate of VEGF enhanced in normal salivary gland tissue, primary PA tissue and recurrent PA tissues stepply （P 〈 0.05） and so did the MVD counted （P 〈0.05） ; MVD tended to depend on VEGF expression levels in PA （P〈 0.05）. Conclusions The expression of VEGF and MVD play an important role in the clinicopathological characters of pleomorphic adenoma.

关 键 词：血管内皮生长因子 微血管密度 多形性腺瘤 

分 类 号：R735.2[医药卫生—肿瘤]