酪氨酸羟化酶与视网膜疾病  

Expression of tyrosine hydroxylase and retinal disease

作　　者：刘政海[1] 万炜[1] 

机构地区：[1]湖南省南华大学医学院解剖学系,湖南衡阳421001

出　　处：《现代生物医学进展》2011年第11期2168-2171,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(NO:30671100)资助

摘　　要：酪氨酸羟化酶(tyrosine hydroxylase,TH)是儿茶酚胺(catecholamines,CAs)合成过程中的限速酶,提高或抑制该酶的活性可大幅度影响CAs的合成。近年来对于TH的关注越来越多,大量的研究表明,TH含量及活性的异常改变能通过影响CAs的含量而导致相应生理功能的异常,从而导致疾病。本文将TH的结构功能、分布、表达变化及其与视网膜疾病关系做一综述。Tyrosine hydroxylase（TH） is the rate-limiting enzyme in the synthesis of catecholamines（CAs）, Enhancing or inhibiting the activity of TH can affect substantially the synthesis of CAs. Recently, it is getting more and more attention. And a large number of studies have shown that the abnormalities of the content and activity of TH lead to the corresponding abnormal physiological function by affecting the concentration of CAs. Here we summarized the current research on its structure and function, disposition, change of its expression and its relation with the retinal disease.

关 键 词：酪氨酸羟化酶 多巴胺 多巴胺能无长突细胞 

分 类 号：R574[医药卫生—消化系统]