基因重组别藻蓝蛋白对小鼠S_(180)肉瘤的抑制作用  

Elementary Study of Recombinant Allophycocyanin(RAPC) on S_(180 ) Tumor in Mice

作　　者：唐书明[1] 黄芳 窦昌贵[1] 庄桂霞[1] 秦松[2] 王希华[2] 邹立红[2] 

机构地区：[1]中国药科大学海洋药物中心,南京210038 [2]中国科学院海洋研究所,青岛266071

出　　处：《药物生物技术》1999年第3期168-170,共3页Pharmaceutical Biotechnology

基　　金：中国生物工程中心"九五"攻关项目!编号 96-C0 2-0 4-0 3

摘　　要：研究基因重组别藻蓝蛋白 (RAPC)的抑瘤作用 ,给皮下接种S180 瘤细胞的小鼠 ,每天分别ig及ipRAPC 13 4mg/kg ,6 7mg/kg和 3 4mg/kg ,共 10d ,第 11d处死小鼠 ,称瘤重和胸腺重 ,计数白细胞。结果表明 ,RAPC对小鼠S180 肉瘤有显著抑制作用 ,瘤重抑制率在 45 %～ 64 %之间 ,ig及ip均有效 ,对荷瘤小鼠的胸腺指数和白细胞数量无明显影响。The mice were infecfed by S 180 , then treated with Recombinant Allophycocyanin(RAPC) ig or ip 13 4mg/kg,6 7mg/kg and 3 4mg/kg per day respectively for ten days The animal were killed, tumor clot or thymus were weighed and the leukocyte were counted The results showed that RAPC could decrease weight of tumor significatly The inhibitory rate ranged from 45% to 64% and had no obvious effect on Thymus Index and leukocyte count

关 键 词：基因重组 别藻蓝蛋白 S180肉瘤 抑瘤 

分 类 号：R979.1[医药卫生—药品] Q784[医药卫生—药学]