MTS_1/p16基因异常表达与胆道恶性肿瘤生物学行为关系  

THE ABNORMAL RELATIONSHIP OF EXPRESSION OF MTS_1/p16 GENE WITH THE BIOLOGICAL BEHAVIOR IN MALIGNANT TUMOR OF BILE DUCT

作　　者：王贵和[1] 赵铁军[1] 夏飞[1] 桑卫东[1] 

机构地区：[1]安徽省铜陵市人民医院,铜陵市244000

出　　处：《肿瘤研究与临床》1999年第5期310-311,共2页Cancer Research and Clinic

摘　　要：了解ＭＴＳ１／ｐ１６基因与胆道恶性肿瘤发生及生物学行为的关系。方法　采用免疫组化方法观察该基因产物ｐ１６蛋白在胆道恶性肿瘤的表达情况。结果ＭＴＳ１／ｐ１６在胆道恶性肿瘤中阳性表达率明显低于胆道良性病变（Ｐ＜０．０１），且与肿瘤的浸润及淋巴结转移密切相关（Ｐ＜０．０１），但与肿瘤的病理类型及分化程度无相关性（Ｐ＞０．０１）。结论检测ＭＴＳ１／Ｐ１６对临床正确估计胆道恶性肿瘤的浸润性、淋巴结转移潜能及判断预后有重要价值。Objective To examine the expression of p16 protein in malignant tumor of bile duct and itsrelationship with tumor behavior. Methods pl6 protein was studied by immunohistochemical method.Results The positive expression rate of MTS,/p16 in malignant tumor was lower than that in benign ones,and had close correlationship with the invasiveness and lymph nodes metastasis (P<0.01 ),except for thepathological categories and differentiation (P>0.01 ). Conclusion The investigation of MTS1/p16 is of .great importance in evaluating the invasiveness of tumor, meta-potential of lymph node and clinicalprognosis.

关 键 词：胆囊癌 胆管癌 P16基因 多肿瘤抑制基因 

分 类 号：R735.802[医药卫生—肿瘤]