脑源性神经营养因子基因多态性与重性抑郁障碍认知功能的关系  

The relation between brain-derived neurotrophic factor gene polymorphism and cognitive function in patients with major depressive disorder

作　　者：张璐璐[1] 郑洪波[1] 宁玉萍[1] 马崔[1] 彭建玲[1] 

机构地区：[1]广州市精神病医院精神科,510370

出　　处：《中华精神科杂志》2011年第2期88-92,共5页Chinese Journal of Psychiatry

基　　金：广州市医药卫生科技基金资助项目（2008-YB-105、201102A213153）

摘　　要：目的 探讨脑源性神经营养因子（BDNF）基因Val66Met多态性与重性抑郁障碍认知功能的关系。方法以100例重性抑郁障碍患者（患者组）与100名健康志愿者（对照组）为研究对象，采用1组神经心理学检测评估认知功能，并检测BDNF基因多态性；分别按照总智商（FIQ）、威斯康星卡片分类测验改良版（M-WCST）分类数、正确数、持续错误数、河内塔测试（TOH）计划时间、执行时间及总分的测验成绩由好到差排序，将患者组分为组1（成绩前50例，认知功能较好的患者）和组2（成绩后50例，认知功能较差的患者），检测组1与组2BDNF基因型频率分布。结果（1）对照组：除数字广度外，其他神经心理学测验成绩在BDNF基因型间的差异均无统计学意义（P〉0．05）。（2）患者组：中国修订韦氏成人智力量表（WAIS—RC）FIQ[（102．1±11．5）分vs（92．5±10．2）分]、M—WCST分类数[（5．6±1．7）分VS（2．9±1．2）分]和正确数[（36．5±6．0）分VS（26．8±5．6）分]、TOH总分[（50．8±9．6）分VS（40．4±9．3）分]及各项测验成绩，连线测验（TMT）A耗时数和B耗时数的成绩在患者组Val/Val基因型均优于Me．Met基因型，差异有统计学意义（P均〈0．01）。（3）组1Met/Met基因型频率分布显著低于组2，差异均有统计学意义（P均〈0．01）；除FIQ和TOH执行时间外，其他各项组1VaL／Val基因型频率显著高于组2，差异有统计学意义（P均〈0．05）。结论BDNF基因VM66Met多态性与重性抑郁障碍患者认知功能损害可能有关。Objective To investigate relationship between brain-derived neurotrophic factor （BDNF） gene Val66Met polymorphism and cognitive function in patients with major depressive disorder. Methods One hundred patients with major depressive disorder and 100 healthy volunteers were included. The cognitive function was assessed by a series of ncuropsychology tests, and BDNF gene polymorphism was detected. Results （ 1 ） In control group, the achievements of all neuropsychology tests except for digit span were not significantly different among ones with different BDNF genotypes （ P 〉 0. 05 ）. （2） In patient group, the achievements of neuropsychology tests such as WAIS-RC （ 102. 1 ± 11. 5 vs. 92.5 ±10.2）, M-WCST （5.6 ±1.7 vs. 2.9 ± 1.2, 36.5±6.0 vs. 26.8 ±5.6）, TOH （50.8 ±9.6 vs. 40.4± 9.3 ）, time for TMT-A and TMT-B, were significantly better in ones with Val/Val genotype than in ones with Met/Met genotype （ P ≤0.01 ）. （ 3 ） The Val/Val genotype frequency in patients with better cognitive function was higher than that in patients with worse cognitive function, while Met/Met genotype frequency was in the opposite direction （ P 〈 0. 05 or P 〈 0. 01 ）. Conclusion The BDNF gene Val66Met polymorphism is possibly correlated with impairment of cognitive function in patients with major depressive disorder.

关 键 词：抑郁 脑源性神经营养因子 基因 多态性 限制性片断长度 认知 

分 类 号：R749.4[医药卫生—神经病学与精神病学]