移植肝缺血/再灌注损伤的研究进展  

Advances in Research on Ischemia/Reperfusion Injury in Liver Transplantation

作　　者：何同梅[1,2] 郑智勇[1,2] 武一曼[3] 

机构地区：[1]福建中医药大学福总教学医院 [2]南京军区福州总医院病理科,福州350025 [3]福建中医药大学中西医结合学院病理学教研组,福州350003

出　　处：《医学综述》2011年第11期1640-1642,共3页Medical Recapitulate

摘　　要：肝移植是治疗终末期肝病最有效的方法,而在肝移植领域缺血/再灌注损伤(IRI)与早期移植肝的无功能和肝功能障碍密切相关。目前对于肝移植的并发症及其防治方法研究很多,也取得了很大的进步,但严重肝脏IRI所引起的移植肝功能受损始终未能解决,影响肝移植的效果。现对肝脏IRI的分子机制、病理学特点、预防及治疗等方面予以综述。Liver transplantation is the most effective treatment of end-stage liver disease,while in liver transplantation field,ischemia-reperfusion injury（IRI） and no functionality or dysfunction of the early transplanted liver are closely related.The complications and prevention methods of liver transplantation have been the focus of a lot of research in recent years,and great progresses have been made.However severe liver IRI caused transplanted liver damage can′t be solved all along,affecting the liver transplantation effect.Here is to give an overview of the molecular mechanisms and pathophysiologic features involved in this type of injury and summarize the protective and treatment strategies in clinical practice today.

关 键 词：肝移植 缺血/再灌注损伤 肝脏缺血预处理 

分 类 号：R735.7[医药卫生—肿瘤]