大肠癌组织中Ang-1、Ang-2及受体Tie-2的表达及意义  

Expression and value of Ang-1,Ang-2 and receptor Tie-2 in colorectal cancer tissue

作　　者：闫巍中[1] 温春阳[2] 张继红[3] 王爱平[3] 王彩芹[3] 史忠新[3] 

机构地区：[1]吉林省吉林市中心医院,吉林吉林132011 [2]北华大学医学部,吉林吉林132011 [3]北华大学第一临床医学院,吉林吉林132011

出　　处：《吉林医学》2011年第13期2501-2505,共5页Jilin Medical Journal

摘　　要：目的:旨在研究促血管生成素-1(Ang-1)、促血管生成素-2(Ang-2)和促血管生成素受体(Tie-2)在大肠癌中的表达,分析Ang-1、Ang-2和Tie-2的表达与大肠癌的组织学分化程度的关系,探讨三者在大肠癌进展中的作用,为大肠癌的临床治疗提供新的靶点。方法:应用免疫组化SP法检测64例大肠癌组织中的Ang-1、Ang-2和Tie-2的表达;RT-PCR检测Ang-1、Ang-2和Tie-2mRNA在大肠癌组织中的的表达。结果:Ang-1、Ang-2与Tie-2在癌组织高、中、低分化程度上的表达呈现为肿瘤的分化程度越低,蛋白与RNA表达越明显(P<0.05)。结论:Ang-1、Ang-2及Tie-2的表达程度与大肠癌的进展呈正相关。Objective To study the expression of Ang-1,Ang-2 and receptor Tie-2 in colorectal cancer tissue,and explore the relationship between the expression of Ang-1,Ang-2 and receptor Tie-2 with the histological differentiation degree,provide new targets for the clinical treatment of colorectal cancer.Method The expression of Ang-1,Ang-2 and receptor Tie-2 in 64 cases of colorectal cancer tissues were detected with immunohistochemistry SP method,the expression of Ang-1,Ang-2 and receptor Tie-2 mRNA in colorectal cancer tissues were detected with RT-PCR.Results The expression of Ang-1,Ang-2 and receptor Tie-2 in colorectal cancer tissues showed that the lower the tumor histological differentiation degree,the higher expression of the protein and RNA（P0.05）.Conclusion The expression degree of Ang-1,Ang-2 and receptor Tie-2 has positive relation with the progression of colorectal cancer.

关 键 词：ANG-1 ANG-2 TIE-2 血管新生 大肠癌 

分 类 号：R735.34[医药卫生—肿瘤]