两种取代黄酮的合成研究  

Synthesis of two substituted flavonoids

作　　者：徐克磊[1] 李鹰[2] 郭举[1] 王晶[3] 陈丹[1] 王淑燕[1] 郑永胜[1] 何金[1] 蔡菁[2] 成丽[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]四川大学生命科学学院,四川成都610065 [3]四川大学华西公共卫生学院,四川成都610041

出　　处：《化学研究与应用》2011年第6期771-775,共5页Chemical Research and Application

基　　金：四川省科技厅(2009JY0034)项目资助

摘　　要：分别以间苯二酚和间苯三酚为原料,首先通过傅克酰基化合成羟基取代苯乙酮,再对羟基进行苄基和甲基保护,然后和3,4,5-三甲氧基苯甲酰氯在酸性条件下经Baker-Venkataram a分子内重排闭环形成目标化合物。Two target compounds were synthesized by the raw materials of resorcinol and phloroglucinol which were acylated to synthesize hydroxyl substituted acetophenone and then the hydroxyls were protected by benzyl bromide and dimethyl sulfate.At last the two polysubstituted flavonoids were synthesized by Baker-Venkataeaman＇s route through intramolecular rearrangement cyclization in the acidic condition.The two target compounds were confirmed by MS,1H-NMR.

关 键 词：黄酮 甲氧基 Baker-Venkataraman 合成 

分 类 号：O621.3[理学—有机化学]