不同多孔PLGA/纳米羟基磷灰石复合支架的制备及机械物理性能研究  

The Study of Different Preparation Methods of Porous PLGA/Nano Hydroxyapatite Composite Scaffold Materials and Their Mechanical Properties

作　　者：尹玉承[1] 胡飞[2] 周东风[2] 吴王喜[2] 

机构地区：[1]广东省深圳市第五人民医院口腔中心,广东深圳518001 [2]广东省口腔医院,广东广州510280

出　　处：《临床医学工程》2011年第6期813-814,共2页Clinical Medicine & Engineering

基　　金：广东省自然科学基金项目"辛伐他汀纳米复合骨支架材料的研究"(编号:9151008901000028)

摘　　要：目的研究不同方式的多孔PLGA/纳米羟基磷灰石复合支架的制备及机械物理性能。方法采用PLGA颗粒和纳米HA颗粒为原料,制作多孔PLGA(产气颗粒沥析技术)、多孔PLGA(溶液浇注/颗粒沥析技术)、纳米羟基磷灰石、多孔PLGA/纳米羟基磷灰石(产气颗粒沥析技术)、多孔PLGA/纳米羟基磷灰石(溶液浇注/颗粒沥析技术)五种支架,分别对支架的抗压强度、孔隙率、保水率等机械物理性能进行研究。结果成功制备五种类型的复合支架,其性能均达到了较好的机械物理效果,其中纳米羟基磷灰石支架的保水率最高,多孔复合支架展现了较好的抗压强度,产气颗粒沥析技术得到了更高的孔隙率。结论多孔PLGA/纳米羟基磷灰石复合支架具有良好的机械物理性能,产气颗粒沥析技术能制备出更高孔隙率的支架材料。Objective To study the different preparation methods of porous PLGA/nano hydroxyapatite composite scaffold materials and their mechanical properties. Methods PLGA particles and nano HA particles were used to make porous PLGA（gas-produced particulate leaching technology） ,porous PLGA（solvent casting/particulate leaching technology） ,nano hydroxyapatite,porous PLGA/nano hydroxyapatite（gas-produced particulate leaching technology） ,porous PLGA/nano hydroxyapatite（solvent casting/particulate leaching technology） . The compressive strength,porosity and water retention rate were studied. Results Five materials were prepared successfully and got good mechanical and physical effects. Among them,the water retention rate of nano hydroxyapatite was the highest,porous composite materials showed good compressive strength,and more porosity was obtained by gas-produced particulate leaching technology. Conclusion Porous PLGA/nano hydroxyapatite composite scaffold material has good mechanical properties,more porosity can be obtained by gas-produced particulate leaching technology.

关 键 词：多孔PLGA 纳米 羟基磷灰石 

分 类 号：R783.1[医药卫生—口腔医学]