人乳头瘤病毒检测在宫颈病变中的应用价值  

Application of human papillomavirus dectection in women with abnormal cervical cytology

作　　者：周莉[1] 陈姗[1] 狄娜[2] 张帝开[1] 

机构地区：[1]中山大学附属第六医院妇产科,广州510655 [2]中山大学附属第二医院妇产科,广州510655

出　　处：《中华实验和临床病毒学杂志》2011年第2期143-145,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的了解宫颈细胞学异常患者中人乳头瘤“毒（HPV）的感染状况，评估HPV检测在宫颈病变筛查中的价值。方法随机选取宫颈薄层液基细胞学检测异常的101例患者进行了HPV检测，同时行组织病理学检查。结果（1）101例宫颈细胞学异常患者中，细胞学为ASCUS、LSIL、HSIL、鳞状细胞癌时高危型HPV阳性率分别为84．2％、88．6％、100．0％和2／2；（2）10l例细胞学异常患者中20例为CINI，81例为CINⅡ及以上级别，高危型HPV阳性率存CINI、CINⅡ及以上级别分别为60％、97．5％；（3）ASCUS组中，高危型HPV阳性患者中CINⅡ及以上病变的发生率为87．5％，HPV阴性患者中CINⅡ及以上病变的发生率为16．7％；（4）高危型HPV型别分布由高到低分别为HPVl6型39．6％（40／101），HPV58型17．8％（18／101），HPV52型16．8％（17／101），HPVl8型9．9％（10／101）以及HPV33型9．9％（10／101）。结论高危型HPV感染率与宫颈病变级别呈正相关；HPV检测可作为ASCUS患者的有效分流手段。宫颈病变患者中高危型HPV感染以16、58、52、18、33型为主。Objective To detect the human papillomavirus（HPV） infectious condition in women with abnormal cytology and evaluate its values in the screening of high grade cervical intraepithelial lesion. Method 101 patients who underwent thinprep cell test（TCT） with abnormal cervical cytology were selected to undergo HPV test, all subjects also received tissue biopsy at the same time. Results （ 1 ） Among the 101 patients,the incidence rates of high risk HPV infection of those with ASCUS,LSIL, HSIL and squamous cell carcinoma were 84.2% ,88.6% , 100.0% and 2/2 respectively. （2） Among the patients with abnormal cytology,the number of patients with pathologically confirmed results of CIN I and CIN Ⅱ or worse were 20 and 81, the incidence rates of high risk HPV infection of those with CIN I and CIN Ⅱor worse were 60. 0% and 97.5% respectively. （3） In the ASCUS group, the incidence rates of CIN Ⅱor worse with high risk HPV infection were 87.5%and the incidence rates of CIN Ⅱ or worse without high risk HPV infection were 16.7%. （4）The prevalence of high risk HPV types from highest to lowest order were follow： HPVI6 （39.6%）,58（17.8%）,52（16.8%）,18（9.9%）,33（9.9%）. Conclusions The infection rate of high risk HPV was positively correlated with the levels of cervical lesions. HPV test is a good triage approach for the patients with ASCUS. HPV16.58.52,18,33 are the most common in the patients of cervical lesions.

关 键 词：乳头状瘤病毒 人 细胞学 宫颈病变 

分 类 号：R737[医药卫生—肿瘤]