Apoptosis and the target genes of microRNA-21  

作　　者：Lindsey E.Becker Buscaglia 

机构地区：[1]Department of Biochemistry and Molecular Biology,School of Medicine,University of Louisville

出　　处：《Chinese Journal of Cancer》2011年第6期371-380,共10页

基　　金：supported by the Diabetes and Obesity Center funded by NCRR/NIH(P20RR024489);the Center for Environmental Genomics and Integrated Biology fundedby NIEHS/NIH(P30ES014443);the Scientist Development Grant from American Heart Association(0830288N);a R01 grant from National Institutes of Health(CA138688)

摘　　要：MicroRNA-21(miR-21) is frequently up-regulated in cancer and the majority of its reported targets are tumor suppressors.Through functional suppression,miR-21 is implicated in practically every walk of oncogenic life:the promotion of cell proliferation,invasion and metastasis,genome instability and mutation,inflammation,replicative immortalization,abnormal metabolism,angiogenesis,and evading apoptosis,immune destruction,and growth suppressors.In particular,miR-21 is strongly involved in apoptosis.In this article,we reviewed the experimentally validated targets of miR-21 and found that two thirds are linked to intrinsic and/or extrinsic pathways of cellular apoptosis.This suggests that miR-21 is an oncogene which plays a key role in resisting programmed cell death in cancer cells and that targeting apoptosis is a viable therapeutic option against cancers expressing miR-21.MicroRNA-21 （miR-21） is frequently up-regulated in cancer and the majority of its reported targets are tumor suppressors. Through functional suppression, miR-21 is implicated in practically every walk of oncogenic life： the promotion of cell proliferation, invasion and metastasis, genome instability and mutation, inflammation, replicative immortalization, abnormal metabolism, angiogenesis, and evading apoptosis, immune destruction, and growth suppressors. In particular, miR-21 is strongly involved in apoptosis. In this article, we reviewed the experimentally validated targets of miR-21 and found that two thirds are linked to intrinsic and/or extrinsic pathways of cellular apoptosis. This suggests that miR-21 is an oncogene which plays a key role in resisting programmed cell death in cancer cells and that targeting apoptosis is a viable therapeutic option against cancers expressing miR-21.

关 键 词：细胞凋亡 microRNA 靶基因 程序性细胞死亡 肿瘤抑制基因 致癌基因 miR 微RNA 

分 类 号：R730.2[医药卫生—肿瘤]