乳腺癌骨转移的危险因素分析  

Analysis of the Risk Factors of bone metastasis after operation for breast cancer in Chinese

作　　者：李凯[1] 于飞[1] 李午生[1] 赵力[1] 邹华伟[1] 

机构地区：[1]中国医科大学附属盛京医院,辽宁沈阳110004

出　　处：《中国医学工程》2011年第5期7-8,12,共3页China Medical Engineering

基　　金：辽宁省教育厅课题资助(课题编号:2007CB512702)

摘　　要：目的分析乳腺癌术后骨转移患者的临床资料,探讨乳腺癌发生骨转移的危险因素。方法运用Kaplan-Meier检验及Cox回归分析对我病房2007～2008年的60例乳腺癌骨转移患者的临床资料进行分析,分析乳腺癌骨转移发生的危险因素。结果乳腺癌确诊及手术时的年龄、腋下淋巴结情况、病理情况、内分泌治疗及化疗与否及Her-2表达等因素对骨转移的发生无明显影响(P>0.05),而ER/PR其一为阳性者骨转移发生的时间为2±0.908年,ER/PR均为阴性者骨转移发生的时间为5±1.815年;Her-2阳性者骨转移发生的时间为2±1.386年,Her-2阴性者骨转移发生的时间为4±1.090年。对因素ER/PR及Her-2进一步分析显示ER/PR阳性的相对危险度为3.771,差异显著(P=0.006),Her-2阳性的相对危险度为0.91,差异无显著性(P=0.884)。结论因素ER/PR阳性是乳腺癌骨转移的独立影响因素。【Objective】 To analysis the risk factors which influence on breast cancer patients who Were bone metastasized after mastectomy.【Methods】 The clinical data of breast cancer patients who underwent treatment in our department from 2007 to 2008 was collected,the patients with bone metastasis was 60 case.The risk factors of bone metastasis after operation for breast cancer was analyzed by Kaplan-Meier and Cox analysis.【Results】 The bone metastasis after operation for infiltrating ductal breast cancer is not related with age,TMN stage,the number of axillary metastatic lymph node,whether finished postoperative radiochemotherapy and the state of Her-2（P0.05）.But it is Significantly related with the state of ER /PR（P0.05）.【Conclusion】 The state of ER /PR is one of the risk factors influencing the incidence of breast cancer among Chinese female.

关 键 词：乳腺癌骨转移 危险因素 ER/PR阳性 

分 类 号：R737.9[医药卫生—肿瘤]