去氧氟尿苷联合放疗治疗中晚期食管癌的临床观察  

Clinical observations of doxifluridine combined with radiotherapy for intermediate and advanced esophageal carcinoma

作　　者：陈高阳[1] 张志胜[1] 

机构地区：[1]江苏省姜堰市人民医院,江苏姜堰225500

出　　处：《实用临床医药杂志》2011年第9期119-121,共3页Journal of Clinical Medicine in Practice

摘　　要：目的观察去氧氟尿苷联合放疗治疗中晚期食管癌的疗效。方法 50例中晚期食管癌患者分为2组,其中放疗+去氧氟尿苷组25例;单纯放疗组25例。2组放射治疗方法相同,均采用常规设野,常规分割外照射,同步放化疗组在每日放疗的同时口服去氧氟尿苷。结果全组病例随访2年以上,放疗增敏组与对照组。结果放疗+去氧氟尿苷组和单纯放疗组组的近期疗效总有效率分别为72%和44%。1、2年生存率分别为72%、52%和56%、32%,放疗+去氧氟尿苷组明显优于单纯放组(P<0.05)。结论去氧氟尿苷联合放疗可作为提高中晚食管癌疗效的一种重要手段,且毒副反应易于耐受。Objective To observe the effect of doxifluridine combined with radiotherapy for intermediate and advanced esophageal carcinoma.Methods Fifty patients with intermediate and advanced esophageal carcinoma were randomly divided into two groups with each having 25 patients.One group received radiotherapy combined with doxifluridine and the other group only received radiotherapy.Results The total effective rate was 72% in concurrent group,and 44% in radiation group（P0.05） respectively.The 1-year and 2-year survival rate was 72%,52% in concurrent group,and 56%,32% in radiation alone group（P0.05）.Conclusion It is possible that doxifluridine as concurrent oral chemotherapy regimen combined with radiotherapy can be selected as an effective treatment for esophageal carcinoma.No serious side effects are observed.

关 键 词：去氧氟尿苷 食管癌 放射疗法 

分 类 号：R735.1[医药卫生—肿瘤]