AFP-L3、AFP和铁蛋白联合检测对肝癌诊断的研究  

Application Value of Combination of AFP-L3、AFP and Ferritin in Diagnosis of Liver Cancer

作　　者：许成新[1] 林黎[1] 石庆新[1] 张桂 

机构地区：[1]浙江省台州医院,浙江台州317000 [2]浙江省台州中医院,浙江台州318001

出　　处：《中国现代医生》2011年第18期235-236,共2页China Modern Doctor

摘　　要：目的探讨甲胎蛋白、甲胎蛋白-L3和血清铁蛋白三种肿瘤标记物联合检测在诊断肝癌中的价值。方法采用化学发光免疫分析技术对84例入选对象进行检测,84例中肝癌患者40例、良性肝病患者20例和健康正常人24例。三组对象进行血清甲胎蛋白(AFP)、血清甲胎蛋白-L3和血清铁蛋白单一指标检测及联合检测。结果 三组比较甲胎蛋白、铁蛋白和甲胎蛋白-L3检测结果,经方差分析分别为F=35.56,F=13.72,F=46.02,P均<0.01,三组间该三种指标差异均有统计学意义,而进行Dunnett-t检验发现,肝癌组与良性肝病组甲胎蛋白、铁蛋白和甲胎蛋白-L3检测值比较tD值分别为23.17,16.45,29.86,(P均<0.01),说明肝癌组该三种指标均显著高于良性肝病组。良性肝病组与健康组这三种指标比较tD值分别为25.78;16.12;21.46,(P均<0.01),说明良性肝病组三种指标均显著高于健康组。结论血清甲胎蛋白、血清甲胎蛋白-L3和血清铁蛋白联合检测可提高肝癌的检出率,提高诊断准确性。Objective To explor the application value of combination of AFP-L3,AFP and Ferritin in diagnosis of liver cancer Methods Eighty-four patients selected to use chemical luminescence immunoassay analysis technology,liver cancer patients were 40 patients,20 patients were benign liver disease patients,24 patients were health,they were detected in AFP-L3,AFP and Ferritin or joint inspection. Results The Ftest of three groups in AFP-L3,AFP and Ferritin were 35.56, 13.72, 46.02 which show obvious statistic significance （P〈0.01）. All the records underwent Dunnett-t test,the test results shows that all the index in liver cancer patients were significantly higher than benign liver disease patients,and the index of benigh liver disease patients were significantly higher than health in AFP-L3,AFP and Ferritin, （P〈0.05）. Conclusion AFP-L3,AFP and Ferritin united detection can improve the detection rate and the diagnostic accuracy of liver cancer.

关 键 词：甲胎蛋白 甲胎蛋白-L3 铁蛋白 肝癌 诊断 

分 类 号：R735.7[医药卫生—肿瘤]