溃疡性结肠炎中血浆同型半胱氨酸和褪黑素水平的关联研究  

The correlation study of the plasma homocysteine and melatonin in ulcerative colitis

作　　者：陈茉莉[1] 梅俏[1] 许建明[1] 胡乃中[1] 方海明[1] 陆春霞[1] 刘晓昌[1] 胡静[1] 

机构地区：[1]安徽医科大学第一附属医院消化科安徽省消化病重点实验室,合肥230022

出　　处：《中华消化杂志》2011年第5期322-324,共3页Chinese Journal of Digestion

摘　　要：目的探讨血浆同型半胱氨酸（HCY）和褪黑素（MLT）水平改变与溃疡性结肠炎（UC）的临床关联。方法收集112例UC患者临床资料，以110名健康体检者为对照。采用高效液相荧光检测法（HPLC-FD）检测血浆HCY、MLT水平，酶联免疫吸附分析（ELISA）法检测血浆叶酸（FA）、维生素B12水平，并分析该四项指标与UC患者临床特征的相关性。结果UC患者血浆HCY水平高于健康对照[（11．27±7．26）μmol／L比（8．19±4．81）μmol／L，P=0．000]，血浆MLT水平低于健康对照[-（49．06±31．40）pg／ml比（64．28±41．16）pg／ml，P=0．008]，血浆FA水平低于健康对照[（7．64±1．95）nmol／L比（9．14±1．23）nmol／L，P=0．005]、血浆维生素B12水平低于健康对照[（108．64±32．22）pmol／L比（112．64±33．33）pmol／L，P=0．004]。UC患者血浆HCY、MLT水平与UC病情分度、病变范围、病程、红细胞沉降率（ESR）、C反应蛋白（CRP）水平无关。UC患者血浆HCY与MLT水平间无明显相关性。结论UC患者血浆HCY水平高于健康对照，MLT水平低于健康对照，但二者间无明显相关性。Objective To explore the clinical correlation of the variation of plasma homocysteine （HCY）, melatonin （MLT） and ulceative colitis （UC）. Methods The clinical data of 112 UC patients was collected, and 110 normal healthy persons as control. The level of plasma HCY and MLT was detected by high pressure liquid chromatography-fluorescence detection （HPLC-FD） method. The level of plasma folate （FA） and vitamin B12 was detected by enzyme-linked immunosorbent assay （ELISA） method. The correlation of these four indexes and UC was analyzed. Results The serum level of HCY in UC patients was significantly higher than that in normal healthy persons [（11.27± 7.26） μmol/L vs （8.19±4.81） μmol/L, P= 0. 000]. The serum level of MLT in UC patients was significantly lower than that in ndrmal healthy persons [（49.06 ±31.40） pg/ml vs （64.28 ±41.16） pg/ml,P=0. 008]. The serum level of FA in UC patients was significantly lower than that in normal healthy persons [（7.64±1.95） nmol/L vs （9. 14±1.23） nmol/L, P=0. 005]. The serum level of vitamin B12 in UC patients was significantly lower than that in normal healthy persons [（108.64±32.22） pmol/L vs （112.64±33.33） pmol/L, P=0.004]. There was no correlation between plasma HCY, MLT and UC disease activity degree, range, disease duration, erythrocyte sedimentation rate （ESR）, or C reactive protein （CRP） in UC patients. There was no significant correlation between MLT and HCY in UC patients. Conclusions The serum level of HCY is higher in UC patients than that in normal control, and MLT is lower than that in normal control. However there is no significant correlation between them.

关 键 词：结肠炎 溃疡性 褪黑激素 半胱氨酸 叶酸 维生素B12 

分 类 号：R574.62[医药卫生—消化系统]