山东省胶东半岛多中心人群骨密度分析研究  

Investigation of the correlation between bone mineral density and bone metabolism index in healthy adults in Jiaodong Peninsula

作　　者：杨春云[1] 邱清芳[1] 翟学君 丛振杰 王洪玲[4] 李淑玲[5] 

机构地区：[1]莱州市人民医院,山东261400 [2]莱州市慢性病防治院 [3]烟台市慢性病防治院 [4]烟台市毓璜顶医院 [5]烟台市烟台山医院

出　　处：《中国骨质疏松杂志》2011年第5期431-434,439,共5页Chinese Journal of Osteoporosis

基　　金：民政部"十一五"期间老年学研究科研项目(民人教科字[2008]47-1-35)

摘　　要：目的探讨山东省胶东半岛沿海地区健康人群骨密度正常参考值、骨密度变化规律和骨质疏松的患病率。方法采用双能X线骨密度仪(DEXA)对胶东半岛沿海地区多中心多阶段整群抽样调查3879名21～89岁居民进行骨密度测量。结果确定了胶东半岛沿海地区21～89岁人群不同性别、年龄别腰椎L2～L4和股骨近端的骨密度正常参考值、骨峰值和患病率。男性腰椎L2～L4骨密度峰值在30～39岁,女性腰椎骨密度峰值在21～29岁;男性股骨近端骨密度峰值在21～29岁,女性股骨近端(Neck和Ward's)骨密度峰值在31～39岁,Troch区骨密度峰值在21～29岁。随着年龄的增加(40岁以上),男女性各部位BMD逐渐下降,女性更为明显,男性腰椎BMD下降程度较轻。男性腰椎50～岁组与60～岁组比较和60～岁组与70～岁组比较、女性腰椎60～岁组与70～岁组比较,差异无统计学意义(P>0.05),其余各组比较差异有显著性意义。腰椎的OP患病率最高,40～岁组和50～岁组男女患病率差异无显著性,60岁以后女性明显高于男性(P<0.001)。50～89岁人群腰椎和股骨骨质疏松症发病率男性为13.37%和2.87%,女性为28.03%和7.0%,男女比较差异有非常显著性(P<0.001)。结论获得胶东半岛健康人群骨质疏松症诊断和治疗的骨密度参考值,为骨质疏松纵向流行病学研究奠定基础。Objective To investigate the relationship between bone mineral density （BMD） and serum levels of bone metabolism index including tartrate-resistant acid phosphatase （TRAP-Sb） , collagen type I carboxy-terminal peptide （CTX）, bone alkaline phosphatase （ BALP）, bone Gla protein （BGP）, calcitonin （CT） , and 25-OH-vitamin D （25-OH-D） in healthy adults in Jiaodong Peninsula of Shandong. Methods Using dual-energy X-ray absorptiometry （DEXA） equipment, BMD was measured among 436 normal people （207 men and 229 women, aged 21-89 years old） in Jiaodong peninsula with a multi-center, multi-staging sampling method. The bone metabolism index was measured using a ELISA analyzer （USA Thermo） and an automatic biochemical analyzer （HITACHI 7600-20）. The 436 subjects were divided into different gender groups with each ten-year of age. SPSS 13.0 software was used for data analysis. Results The levels of TRAP-Sb, CTX-1, BALP, and BGP were not significantly different between the two genders in the 21-49 year group. Those were different in the 50-89 year group, being higher in the female than in the male. TRAP-Sb and CTX were negatively correlated with BMD. BALP and BGP increased in the 50-69 year group in females, and they were negatively correlated with BMD. The values decreased after 70 years old. 25-OH-D was positively correlated with BMD. CT decreased in the 60-89 year age group, and it was positively correlated with BMD. Serum Ca and P were no significant difference. Conclusion Themeasurement of bone metabolism index provided a significant technical method for monitoring bone mass and early diagnosis of osteoporosis. The ratio of bone formation markers and bone resorption markers was different females of different age. Bone turnover increased in the postmenopausal women.

关 键 词：胶东半岛 骨密度 双能X线骨密度仪 骨质疏松症 患病率 

分 类 号：R363.1[医药卫生—病理学]