低纤维蛋白原对重型颅脑损伤病人术中脑膨出的影响及处理的研究报告  

The study on the effect and the treatment of Low fibrinogen to brain swelling of the Severe Craniocerebral Injury patients

作　　者：孙桂好 孙宏亮[1] 王海鹏[1] 

机构地区：[1]山东省安丘市人民医院,山东安丘262100

出　　处：《医学信息（中旬刊）》2011年第6期2563-2564,共2页Medical Information Operations Sciences Fascicule

摘　　要：目的:研究低纤维蛋白原对重型颅脑损伤病人术中急性脑膨出的影响及应用冷沉淀防治术中急性脑膨出的效果。方法:随机选取具备相似条件的重型颅脑损伤病人,根据术前纤维蛋白原检查结果,分为低纤维蛋白原组(以下称甲组)100例,正常纤维蛋白原组(以下称乙组)100例,低纤维蛋白原补充冷沉淀组(以下称丙组)100例。根据术中急性脑膨出的程度分别评价为:无脑膨出记为优,轻度脑膨出记为良,恶性脑膨出记为差,然后分别进行甲组和乙组比较,甲组和丙组比较。结果:乙、丙两组的优、良占有率(分别为93%,91%)均明显高于甲组(78%),存在显著性差异(P<0.05)。结论:低纤维蛋白原会明显加重重型颅脑损伤病人术中急性脑膨出的机率和程度,输注冷沉淀能明显改善低纤维蛋白原引发的脑膨出的机率和程度。Objective：To study the effect of Low fibrinogen to brain swelling of the Severe Cranioeerebral Injury patients, and the effect of cryoprecipitate to acute brain swelling. Methods：The Craniocerebra] Injury patients with similar conditions according to the preoperative fibrinogen test results, were divided into low fibrinogen group （Group A） ,f normal fibrlnogen group （group B） and low fibrinogen combining cryoprecipitate group （Group C）, 100 cases in each group. Evaluating the effect according the degree of Acute brain swelling as follows：no brain swelling recorded as excellent, mild brain swelling recorded as benign or malignant brain swelling reCor- ded for the poor. And then compare Groups A and B ,Group A and Group C respectively. Results：The rate of excellent,good in B,C groups （93% ,91% ） were significandy higher than Group A （78 % ）, there was significant difference （ P 〈 0.05 ）. Conclusion ： Low fibrinogen significantly increased the probability of acute brain swelling in patients with Craniooerebral Injury patients, can significantly improve the infusion of cryoprecipitate can relieve the extent of brain swelling induced by fibrinogen.

关 键 词：纤维蛋白原 重型颅脑损伤 急性脑膨出 冷沉淀 

分 类 号：R742[医药卫生—神经病学与精神病学]