CT检查联合VEGF-C表达检测在非小细胞肺癌淋巴结转移诊断中的价值  

Diagnosis value of CT examination combined with VEGF-C expression in lymph node metastasis of the non-small cell lung cancer

作　　者：张欣贺[1] 施雪峰[2] 王志铭[3] 杨红耀[1] 曹阿丹[1] 

机构地区：[1]辽宁医学院研究生院,辽宁锦州121000 [2]锦州市中心医院放射线科,辽宁锦州121000 [3]辽宁医学院附属第三医院放射线科,辽宁锦州121000

出　　处：《东南大学学报（医学版）》2011年第3期460-463,共4页Journal of Southeast University(Medical Science Edition)

摘　　要：目的:探讨CT检查联合VEGF-C表达检测的方法对非小细胞肺癌淋巴结转移的诊断价值。方法:46例经手术病理证实的非小细胞肺癌患者术前行CT平扫及增强扫描,术后行免疫组化染色检测肿瘤组织VEGF-C表达,分析两种方法及两种方法联合应用对纵隔淋巴结转移的诊断价值(以术后淋巴结病理结果为标准)。结果:对纵隔淋巴结转移的诊断,CT检查的敏感性为65.00%,特异性为80.77%,诊断符合率为73.91%。VEGF-C阳性表达检测的敏感性为90.00%,特异性为65.38%,符合率为76.09%。两种方法联合,其敏感性为95.00%,特异性为88.46%,符合率为91.30%,符合率显著高于单一检查方法,差异有统计学意义(P<0.05)。结论:CT检查联合VEGF-C表达检测能提高非小细胞肺癌纵隔淋巴结转移的诊断符合率,对非小细胞肺癌患者的诊断、治疗和改善预后有重要临床意义。Objective： To evaluate the diagnosis value in non-small cell lung cancer lymph node metastasis by CT examination combined with the expression of vascular endothelial growth factor- C （ VEGF- C ） detection. Methods： Fortysix cases with non-small cell lung cancer confirmed by surgery and pathology were examined with plain and enhanced CT scanning, the resected tumor specimens were immunohistochemically stained for measuring VEGF-C expression. We analysed the diagnositic value of mediastinal lymph node metastasis by two methods and the method combined two methods （lymph node pathology results were as the standard）. Results： To mediastinal lymph node metastasis in non-small cell lung cancer, sensitivity of CT examination was 65.00%, and specificity was 80.77% , the diagnostic coincidence rate was 73.91%. The positive expression of VEGF-C sensitivity was 90.00% , specificity was 65.38% , the coincidence rate was 76.09%. Sensitivity of combined two methods was 95.00% , specificity was 88.46% , the coincidence rate was 91.30%, the diagnostic coincidence rate was higher than that with single method and it had significant difference （P 〈 0.05 ）. Conclusion： The method of CT examination combined VEGF-C expression can improve the diagnostic coincidence rate of non-small cell lung cancer mediastinal lymph node metastasis. It has a vital significance on diagnosis, treatment and improving prognosis in patients with non-small cell lung cancer.

关 键 词：非小细胞肺癌 多层螺旋CT 血管内皮生长因子-C 淋巴结转移 

分 类 号：R734.2[医药卫生—肿瘤] R730.4[医药卫生—临床医学]