乳腺癌化疗药物耐药性的机制浅析  

Mechanisms of drug resistance to in breast cancer chemotherapy

作　　者：赵博[1] 黎瀚[1] 王知勇[1] 

机构地区：[1]中国医科大学临床医学系,七年制辽宁沈阳110000

出　　处：《中国当代医药》2011年第17期9-10,共2页China Modern Medicine

摘　　要：恶性肿瘤对化疗药物产生耐药是困扰各种肿瘤治疗的共同难题,同样在乳腺癌的治疗中,这也是导致化疗失败的重要原因。化疗药物耐药性的产生涉及一系列的机制,包括药泵表达增加,βⅢ微管蛋白亚型过度表达,TopoⅡ水平下降,抑癌基因突变,解毒作用增强等。只有充分了解其相关机制,才能指导临床,合理用药,降低耐药的发生率,并有效推动基因组学的广泛应用,研发出不同作用机制的抗肿瘤药物,改善乳腺癌和其他恶性疾病的治疗现状。Resistance to chemotherapy is the common problem to treatments of any malignant tumor.It＇s also the important reason which induces the failure of breast cancer chemotherapy.Drug resistance can occur due to various mechanisms including the high expression of drug pump,the overexpression of βⅢ-tubulin isotypes,the decrease of TopoⅡ level,the mutation of anti-oncogene,the enhancement of deintoxication and so on.Only to be familiar to the mechanisms,we can give clinical opinions,make sure the rational use of drug,decrease the risk for drug resistance,increase the application of pharmacogenomics to develop different antineoplastic agent,improve the treatments of breast cancer and other malignant tumor types at last.

关 键 词：乳腺癌 化疗药物 耐药 作用机制 

分 类 号：R737.9[医药卫生—肿瘤]