星形胶质细胞功能异常诱发癫痫机制的研究进展  

Progress on molecular basis of astrocyte dysfunction in epilepsy pathogenesis

作　　者：雷慧[1] 李海涛[1,2] 

机构地区：[1]南京中医药大学药学院,江苏南京210046 [2]澳门科技大学中医药学院,澳门999078

出　　处：《中国药理学通报》2011年第6期752-755,共4页Chinese Pharmacological Bulletin

基　　金：澳门科学技术发展基金资助项目(No027/2007/A2)

摘　　要：癫痫是一种由于大脑神经元异常同步放电引起的脑功能障碍综合征,发病机制迄今尚未完全阐明。近年来越来越多的实验与临床研究显示,星形胶质细胞在癫痫的病理过程中起到了重要作用,有可能成为药物干预癫痫的新靶点。该文综述了星形胶质细胞由于功能以及与神经元之间信号调控异常从而诱发癫痫的分子机制的研究进展。Epilepsy is defined as a cerebral disorder induced by abnormal synchronous discharge of neurons.The physiopathological basis controlling this neurological disease has not been fully understood.More recently,increasing evidence has suggested a critical role of astrocyte dysfunction in epilepsy pathogenesis.Astrocytes are emerging as a potential target for pharmacological intervention of epilepsy.This review focuses on the mechanisms underlying the cellular and molecular abnormalities of astrocytes that are currently thought to be associated with human or experimental epilepsy.

关 键 词：癫痫 海马硬化 星形胶质细胞 功能异常 钾离子通道 谷氨酸 缝隙连接 

分 类 号：R-05[医药卫生] R322.81