自体骨髓干细胞移植术后门静脉血流动力学变化的研究  

The study of portal vein hemodynamics changes after autologous bone marrow stem cell transplantation

作　　者：何春萍[1] 刘黎[1] 

机构地区：[1]武汉科技大学附属天佑医院感染科,430064

出　　处：《中国综合临床》2011年第6期587-589,共3页Clinical Medicine of China

摘　　要：目的观察肝硬化患者自体骨髓干细胞移植术后门静脉血流动力学的变化。方法应用彩色多普勒超声测量50例自体骨髓干细胞移植术后门静脉血流动力学指标，自术前至术后6个月进行定期随访。记录门静脉内径、门静脉平均血流速度及脾脏厚度，比较自体骨髓干细胞移植前后三者的变化情况。结果（1）术后1、3、6个月各时段门静脉内径分别为（1．41±0．15）、（1．38±0．11）、（1．36±0．17）cm，与术前（1．53±0．18）cm比较明显减小，差异均有统计学意义（t值分别为1．987、1．994、1．976，P均〈0．05），但术后各时段比较差异无统计学意义（F值为2．35，P〉0．05）。（2）术后1、3、6个月各时段门静脉血流速度值分别为（15．7±3．6）、（16．1±2．4）、（15．9±3．0）cm／s，与术前（11．4±3．3）cm／s比较明显增加，差异均有统计学意义（t值分别为2．345、2．460、2．381，P均〈0．01），但术后各时段比较差异无统计学意义（F值为2．14，P〉0．05）。（3）术后1、3、6个月各时段脾脏厚度分别为（4．8±0．3）、（4，7±0．6）、（4．8±0．5）om，与术前（5．2±0．7）cm比较明显缩小，差异均有统计学意义（t值分别为2．289、2．390、2．425，P均〈0．01），但术后各时段比较差异无统计学意义（F值为2．26，P〉0．05）。结论自体骨髓干细胞移植术可以有效增加门静脉血流速度，并使脾脏缩小，从而降低门静脉压力，减轻门静脉高压。Objective To study portal vein hemodynamics changes after autologous bone marrow stem cell transplantation in patients with liver cirrhosis. Methods The hemodynamic parameters, including portal vein diameter, average portal blood flow velocity and spleen size, were determined by Colour Doppler Ultrasonography in 50 patients after autologous bone marrow stem cell transplantation and all cases were followed for up to 6 months. Results （ 1 ） After autologous marrow stem cell transplantation, the portal vein diameter reduced significantly at different timepoints compared to before the treatment （ [ 1.41±0. 15 ] cm, [ 1.38±0. 11]cm,[1.36±0. 17]cm vs. [1.53±0. 18] cm,t = 1. 987,1. 994, 1.976,Ps 〈0.05）,but we found no significant difference in the comparisons among different timepoints （ F = 2. 35 ,P 〉 0. 05 ）. （ 2 ） After autologous marrow stem cell transplantation, the average portal blood flow velocity increased significantly at different timepoints compared to before the treatment （ [ 15. 7±3.6] cm/s, [ 16. 1 ±2.4 ] cm/s, [ 15. 9±3.0 ] cm/s vs.[ 11.4±3. 3 ] cm/s, t = 2. 345,2. 460, 2. 381, Ps 〈 0. 01 ）, but we found no significant differences in the comparisons among different timepoints （ F = 2. 14, P 〉 0. 05 ） . （ 3 ） After autologous marrow stem cell transplantation,the spleen size reduced significantly at different timepoints compared to before the treatment （[4. 8±0. 3]cm, [4. 7±0. 6]cm, [4. 8±0. 5] cm vs. [5.2±0. 7] cm,t = 2. 289,2. 390,2. 425,Ps 〈 0. 01 ）, but we found no significant differences in the comparisons among different timepoints （ F = 2. 26, P 〉 0. 05 ） . Conclusion The autologous bone marrow stem celt transplantation can effectively improve the portal vein blood flow, reduce the spleen size, alleviate portal hypertension in patients with liver cirrhosis.

关 键 词：干细胞移植 门静脉 血流动力学 

分 类 号：R575.2[医药卫生—消化系统]