间断短时血液滤过对重症急性胰腺炎患者血浆炎性细胞因子的影响  

Effects of intermittent hemofiltration on the protein levels of plasma inflammatory cytokines of severe acute panreatitis patients

作　　者：白云[1] 

机构地区：[1]河北省邢台市人民医院消化内科,054000

出　　处：《免疫学杂志》2011年第6期550-552,共3页Immunological Journal

摘　　要：目的观察间断短时血液滤过对重症急性胰腺炎血浆炎性细胞因子的影响。方法重症胰腺炎病人经过短时、重复血液滤过后,酶联免疫吸附法测定血浆TNF-α、IL-6和IL-8水平。结果血滤组与非血滤组住院第4天TNF-α及IL-8评分差异有统计学意义(P<0.05或P<0.01),住院第10天2组IL-6、IL-8及APACHEⅡ差异均有统计学意义(P<0.01)。结论间断血液滤过治疗在控制病情、减轻或缩短SIRS上较非血滤组优越,提示该方法有推广应用潜力。Severe acute pancreatitis（SAP） is a severe disease,a threat to patients＇ life.During SAP,large amounts of inflammatory cytokines are released to the blood plasma,which subsequently cause systemic inflammatory response syndrome in patients.It has been shown that high flow hemofiltration strategy is beneficial to clear up the blood inflammatory cytokines.In this study,we try a new strategy,intermittent hemofiltration,to observe the efficiency of the clearance of blood inflammatory cytokines in SAP patients by measuring TNF-α,IL-6 and IL-8 by ELISA assay.We found that patients treated with intermittent hemofiltration method had significantly lower levels of TNF-α and IL-8 in plasma at 4 days post treatment,and markedly lower levels of TNF-α,IL-6 and IL-8 levels at day 10 post treatment,as compared with control group.Results indicate that this new strategy has an advantage over the currently established methods on the clearance of inflammatory cytokines in SAP patients,and suggest its potential extended application in the future.

关 键 词：重症急性胰腺炎 细胞因子 TNF-α IL-6 IL-8 

分 类 号：R576[医药卫生—消化系统]