降压治疗对高龄高血压患者认知功能的影响  

A study of effect of anti-hypertension treatment on cognitive function in elderly patients with hypertension

作　　者：姜秋波 高常涛 邹旭明 隋辉 刘振东[2] 

机构地区：[1]山东省烟台市莱州荣军医院,261400 [2]山东省医学科学院基础医学研究所心脑血管病防治研究中心

出　　处：《临床精神医学杂志》2011年第3期162-164,共3页Journal of Clinical Psychiatry

基　　金：山东省自然科学基金项目(ZR2009CL029);山东省卫生厅资助项目(2009HW080)

摘　　要：目的:探讨降压治疗对高龄高血压患者认知功能的影响。方法:183例80岁以上的高龄高血压患者随机分为治疗组94例和对照组89例。治疗组给予吲哒帕胺单用或联合使用卡托普利治疗,对照组给予安慰剂治疗,观察期1年。采用在简易智能状态检查(MMSE)基础上略加修改的认知量表,对两组患者进行认知功能检测。结果:治疗组MMSE总分、定向力、注意力和计算力以及语言能力治疗后较治疗前有所提高,治疗前后改变率分别为(0.53±0.14)%、(0.74±0.17)%、(1.28±0.10)%以及(0.55±0.09)%,而对照组MMSE总分、定向力、注意力和计算力以及语言能力治疗后较治疗前降低,治疗前后改变率分别为(-2.49±0.52)%、(-3.53±0.66)%、(-11.92±3.64)%以及(-2.85±0.69)%,两组间比较,差异有统计学意义(t分别=1.507,1.853,3.154,1.611;P分别=0.021,0.015,0.000,0.019)。两组回忆力治疗后均下降,以对照组下降率显著大于治疗组,两组间比较,差异有统计学意义(t=3.439,P=0.000)。两组治疗后记忆力下降率比较,差异无统计学意义(t=0.137,P=0.432)。结论:降压治疗对高龄高血压患者认知功能的损伤有延缓和保护作用。Objective：To explore the effect of anti-hypertension treatment on cognitive function in elderlyr patients with hypertension. Method：180 elderly patients with hypertension aged more than 80 years old were randomly divided into two groups, treatment group （n = 94, treated by indapamide or indapamide combined with captopril） and control group （ n = 89, treated by placebo） ,for 1 year treatment. Patients of the two groups were tested by cognitive function scale derived from the modified mini-mental state examination （MMSE）. Results： There were significant improvement in patients of treatment group after treatment in the total score of MMSE and the sub-scores in orientation, attention, calculation and language, compared with before treatment （0.53 ±0. 14）%, （0.74±0.17）% ,（1.28 ±0. 10）% and （0.55 ±0.09）%. However, the scores of the items above in control group were significantly lower after treatment compared with treatment before （ - 2.49 ± 0.52） %, （ - 3.53 ±0.66） %, （ - 11.92 ±3.64） % and （ - 2.85 ± 0.69） %. There were significant differences in the changes of the above items between the two groups （t = 1. 507, 1. 853, 3. 154,1. 611 ; P = 0.021,0.015,0.000,0. 019）. Patients in both groups had lower recollection capability after treatment, significantly lower in control group （t = 3.439,P = 0.000）. There was no significant difference in the decrease of memory capability in both groups after treatment. Conclusion：Anti-hypertension treatment can have protective effect on cognitive function and postpone the impairment of cognitive function in elderly patients with hypertension.

关 键 词：高血压 高龄 认知功能 降压治疗 

分 类 号：R749[医药卫生—神经病学与精神病学]