新型苯二氮卓类药物L-838,417对三叉神经痛大鼠机械痛行为的影响  

Effect of L-838,417 on pain behavior in a rat model of trigeminal neuralgia

作　　者：龚政[1] 熊源长[1] 

机构地区：[1]第二军医大学长海医院麻醉科,上海200433

出　　处：《南方医科大学学报》2011年第5期890-893,共4页Journal of Southern Medical University

摘　　要：目的观察新型苯二氮卓类药物L-838,417对三叉神经痛大鼠机械痛行为的影响。方法健康雄性SD大鼠随机分为模型组、假手术组及正常对照组,采用经颧骨下缘入路建立大鼠三叉神经分支眶下神经慢性缩窄环术来建立模型。取模型制备成功的大鼠30只作为模型组,随机分为5组:L-838,4171.0mg/kg组(L1组),L-838,41710.0mg/kg组(L10组),吗啡5mg/kg组(M组),安定3mg/kg组(D组)及生理盐水组(NS组),采用Von-Frey法于给药后每1h测各组大鼠触须垫部机械痛阈变化,并于各组痛阈达最高时进行镇静实验,进行姿势评分及翻正反射评分。L1组L10组及M组连续给药10d,每天测各组所能达到的最高疼痛阈值,观察药物耐受情况。结果各组大鼠疼痛基础阈值无统计学差异(P>0.05)。模型组术后第9天疼痛阈值较术前明显降低(P<0.01),术后第9～18天,其疼痛阈值明显低于sham组(P<0.01)。模型组各组给药后,除NS组给药前后阈值无变化(P>0.05)外,其余4组给药后1h疼痛阈值明显增加(P<0.01),4组疼痛最高阈值无统计学差异(P>0.05)。NS组、L1组及L10组均没有出现异常姿势和翻正反射。连续给药后,M组第3天最高疼痛阈值明显下降,与第1天相比有统计学差异(P<0.01),L1组及L10组与第1天比较均无统计学差异(P>0.05)。结论 L-838,417对三叉神经痛大鼠具有良好的抗痛觉过敏作用,且不会带来镇静及运动损害等副作用,长期给药不会产生药物耐受。Objective To investigate the effect of L-838,417 on the results of behavioral test in rats with experimentally induced trigeminal neuralgia. Methods Male SD rats were randomized into model group（n=34） ,sham-operated group（n=30） and control group（n=6） . Thirty rats with trigemina neuralgia induced by chronic constriction injury of the infraorbital nerve below the zygomatic bone were randomly divided into 5 equal groups for treatment with 1.0 mg/kg L-838,417（L1 group） ,10.0 mg/kg L-838,417（L10 group） ,5 mg/kg morphine（M group） ,3 mg/kg diazepam（D group） ,or normal saline（NS group） . The pain threshold of the tentacles pad to von-Frey filament stimulation was measured in the rats before and at 1,2,3,4,5 h after the treatments. The sedative effect of L-838,417 was evaluated by recording the position scores and righting reflex scores,and the drug tolerance was also evaluated. Results Nine days after the operation,the pain threshold of the rats in the model group was significantly decreased compared with that before operation and that of the sham group（P0.01） . The threshold of L1 and L10 groups were both significantly increased 1 h after L-838,417 administration（P0.01） . The rats in the NS,L1,and L10 groups did not show unusual posture or righting reflex. In L1 and L10 groups,L838,417 did not show attenuated efficacy after prolonged use（10 days） . Conclusion L-838,417 can effectively improve hyperalgesia in rats with trigeminal neuralgia without causing sedation,motor impairment,or drug tolerance.

关 键 词：三叉神经痛 L-838 417 吗啡 安定 GABAA受体 

分 类 号：R745.11[医药卫生—神经病学与精神病学]