转录因子Oct-4在皮肤鳞状细胞癌、脂溢性角化病的组织表达及其意义  

Expression of Oct-4 transcription factor in squamous cell skin carcinoma and seborrheic keratosis

作　　者：李毓阳[1] 戴永江 邓斌 粱雄安 谢志杰[1] 陈海富[1] 

机构地区：[1]海南省农垦三亚医院皮肤科,海南三亚572000 [2]海南省医学院附属医院皮肤科,海南海口570102

出　　处：《南方医科大学学报》2011年第5期917-918,共2页Journal of Southern Medical University

摘　　要：目的检测干细胞转录因子Oct-4皮肤鳞状细胞癌(SCC)、脂溢性角化病(SK)的组织表达,分析其表达差异及与肿瘤干细胞的关系。方法采用免疫组织化学方法检测Oct-4在35例SCC、21例SK及15例正常对照皮肤组织中的表达。结果 Oct-4在正常皮肤组织表达为阴性,在SCC、SK之间表达有显著性差异(P<0.05),间接反映SCC、SK的恶性程度不同。结论 SCC、SK中表达Oct-4基因的细胞很可能是SCC、SK的干细胞,这将为其最终分离和鉴定人SCC、SK干细胞提供重要基础,将有助于揭示SCC、SK的肿瘤起始细胞,从而对预防和治疗SCC、SK有重大意义。Objective To detect the expression of stem cell transcription factor Oct-4 in squamous cell carcinoma（SCC） and seborrheic keratosis（SK） and its association with cancer stem cells. Methods Immunohistochemistry was used to detect Oct-4 expression in 35 SCC cases,21 SK cases and 15 normal control skin tissues. Results Oct-4 expression was negative in normal skin and showed a significant difference between SCC and SK tissues（P0.05） . Conclusion The Oct-4-positive cells in SCC and SK are probably tumor stem cells. Oct-4 expression may provide an important evidence for isolation and identification of human SCC and SK stem cells.

关 键 词：OCT-4 皮肤鳞状细胞癌 脂溢性角化病 肿瘤干细胞 

分 类 号：R739.5[医药卫生—肿瘤]