兔VX2移植性骨肿瘤模型超声影像学表现  

Sonographic features of transplantable VX2 bone tumor model in rabbit

作　　者：陈莉[1] 姜立新[1] 郭倩[1] 胡兵[1] 

机构地区：[1]上海交通大学附属第六人民医院超声科,上海200223

出　　处：《声学技术》2011年第2期153-157,共5页Technical Acoustics

摘　　要：建立兔VX2移植性骨肿瘤模型,为高强度聚焦超声(HIFU)治疗骨肿瘤提供理想的实验动物模型。将VX2瘤块植入到20只兔的右侧胫骨髓腔内建立骨肿瘤模型,连续进行超声和磁共振影像学检查并观察其生长特性,确定HIFU治疗骨肿瘤的最佳时间。结果表明成瘤率达100%,1～2周肿瘤在髓内生长,超声可观察肿瘤引起的骨膜反应,2～3周肿瘤开始破坏骨皮质,超声可观察到髓内肿瘤及向髓外软组织侵犯情况,3～4周肿瘤中心有坏死及液化,并开始出现远处转移。可见超声可监测VX2骨肿瘤生长情况,HIFU治疗VX2骨肿瘤模型最佳时间为植瘤后3周左右。Objective：To establish experimental rabbit model with VX2 malignant bone tumor as an ideal experimental animal model for high intensity focused ultrasound（HIFU） treatment in bone tumor.Methods：Twenty New Zealand white rabbits were inoculated with VX2 tumor in cavitas medullaris of right tibia and taken sequential ultrasound and magnetic resonance imaging（MRI） examination to observe growth characteristics and make sure of the best time for bone tumor treatment with HIFU.Results：20 rabbits were all successfully inoculated.Tumor growed in the local ca-vitas medullaris of tibia and periosteal reaction could be observed on sonography in 1-2nd week,cortical bone of tibia were destroyed,soft tissues outside of bone were invaded on sonography image in 2-3th week.Necrosis and liquification in the center of the tumor could be seen on sonography,and metastasis also could be found in other part of the body in 3-4th week.Conclusion：Combined with sonography characteristics of the VX2 tumor in cavitas medullaris of right tibia,it is clear that 3 weeks after tumor transplantion is the best time for VX2 bone tumor model treatment of HIFU.

关 键 词：骨肿瘤动物模型 超声造影剂 磁共振 

分 类 号：R730.59[医药卫生—肿瘤]