小剂量尿激酶对短暂性脑缺血发作患者凝血及纤溶系统的影响研究  

Study on the Influence of Low Dose Urokinase on the Coagulation and Fibrinolytic System for the Patients with Transient Ischemic Attack

作　　者：杨春水[1] 李建英[1] 李雯飞[1] 杨志刚[1] 林勤郁[1] 金明月[1] 

机构地区：[1]广东省深圳市南山区人民医院神经内科,广东深圳518052

出　　处：《河北医学》2011年第6期720-722,共3页Hebei Medicine

摘　　要：目的:探讨小剂量尿激酶对短暂性脑缺血发作患者凝血及纤溶系统的影响。方法:选取2007年10月至2010年10月于本院进行治疗的56例短暂性脑缺血发作患者为研究对象,将其随机分为对照组(常规治疗组)28例和观察组(常规治疗联合小剂量尿激酶组)28例,将两组患者的3d及7d内的发作次数、持续时间及治疗前后的凝血、纤溶指标进行比较。结果:经研究比较发现,观察组的3d及7d内的发作次数少于对照组,持续时间短于对照组,血APTT及PT均长于对照组,FIB及PAI水平均高于对照组,血清DD及t-PA水平均低于对照组,有显著性差异。结论:小剂量尿激酶可显著改善短暂性脑缺血发作患者凝血及纤溶系统。Objective：To study the influence of low dose urokinase on the coagulation and fibrinolytic system for the patients with transient ischemic attack.Method：56 patients with transient ischemic attack in our hospital from October 2007 to October 2010 were selected as research object,and they were randomly divided into control group（routine treatment group） and observation group（routine treatment combined with low dose urokinase group）,each with 28 cases,then the attack times in 3 days and 7 days,duration and coagulation and fibrinolytic system before and after the treatment were detected and compared.Result：The attack times in 3 days and 7 days of observation group were less than those in observation group,duration was shorter than that of control group,serum APTT and PT were longer than those of control group,FIB and PAI were higher than those of control group,DD and t-PA were lower than those of control group,there were significant differences.Conclusion：The low dose urokinase can improve the coagulation and fibrinolytic system of the patients with transient ischemic attack.

关 键 词：小剂量尿激酶 短暂性脑缺血发作 凝血系统 纤溶系统 影响 

分 类 号：R743.3[医药卫生—神经病学与精神病学]