帕罗西汀联合奥氮平治疗抑郁症的临床效果和安全性分析  

The clinical effect and safety of paroxetine combined with olanzapine used for therapy of depression

作　　者：皇甫丽[1] 

机构地区：[1]广东药学院附属第一医院,广州510600

出　　处：《国际医药卫生导报》2011年第11期1368-1370,共3页International Medicine and Health Guidance News

摘　　要：目的探讨帕罗西汀联合奥氮平治疗抑郁症的临床效果和安全性。方法80例抑郁症患者作为研究对象被随机分为实验组和对照组，对照组给予帕罗西汀治疗，实验组在对照组基础上加用奥氮平治疗。结果（t）实验组显效率和总有效率均显著优于对照组（Х^2=3．905，P〈0．05；Х^2=4．507，P〈0．05）。（2）两组均未发生严重副反应，副反应率差异无显著性（Х^2=0．060，P〉0．05）。结论帕罗西汀联合奥氮平治疗抑郁症，具有更好的治疗效果，而且风险性是可控的，值得在临床应用和推广。Objective To explore the clinical effects and safety of using paroxetine and olanzapine to treat depression.Methods Selected 80 cases of patients with depression as studied object, and randourly divided them into experimental group and control group. Control group was treated with paroxetine; while experimental group was treated with paroxetine and olanzapine, Results （1） The efficiency rate and total effective rate in experimental group are significantly better than that in control group（Х^2=3.905, P 〈 0.05; Х^2=4-507, P〈 0.05 ）. （2） There is no serious side-effect that happened in two groups, and the side-effect rates in two groups have no significant difference （ Х^2=0.060, P 〉 0.05 ）. Conclusions Using paroxetine and olanzapine to treat depression has better clinical effect, and the risk can be controlled, so it deserves to apply and prompt it on clinical work.

关 键 词：帕罗西汀 奥氮平 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]