HIF-1α与VEGF165在胃癌的表达及其意义  

Expressions and significance of HIF-1α and VEGF165 in gastric carcinoma

作　　者：孙旭东[1] 欧希龙[1] 关云艳[2] 孙为豪 余磊[1] 叶强[1] 罗培培[1] 袁翠林[1] 

机构地区：[1]东南大学医学院附属中大医院消化病科,南京市210009 [2]无锡市中医院ICU [3]南京医科大学第一附属医院老年消化病科

出　　处：《江苏医药》2011年第11期1288-1290,F0002,共4页Jiangsu Medical Journal

摘　　要：目的探讨缺氧诱导因子1α(HIF-1α)和血管内皮生长因子165(VEGF165)在胃癌中的表达及其与临床病理特征的关系。方法应用免疫组化SP法检测58例胃癌组织和相应癌旁组织中VEGF165和HIF-1α的表达。结果胃癌组织的HIF-1α和VEGF165阳性表达率为74.13%和77.58%,均明显高于相应癌旁组织的12.07%和15.51%(P<0.05)。胃癌组织中HIF-1α和VEGF165的表达与淋巴结转移和临床分期显著相关(P<0.05);且HIF-1α与VEGF165蛋白在胃癌中表达呈正相关(P<0.05)。结论 HIF-1α与VEGF165的高表达可能与胃癌的侵袭、淋巴结转移有关,同时两者呈明显的正相关;联合检测HIF-1α和VEGF165有助于评估胃癌侵袭和转移的生物学行为。Objective To investigate the expressions of hypoxia-inducible factor-1α（HIF-1α） and vascular epithelial growth factor（VEGF）165 in gastric carcinoma and its association with clinicopathological features.Methods The expressions of HIF-1a and VEGF165 protein in 58 gastric cancer and tumor-adjacent normal tissues were detected by immunohistochemistry.Results The positive expression rates of HIF-1α protein and VEGF165 in gastric tissue were 74.13% and 77.58%,which were significantly higher than 12.07% and 15.51%,respectively,in the tumor-adjacent normal tissues（P0.05）.The expressions of HIF-1α and VEGF165 protein were positively correlated to lymph node metastasis and clinical staging（P0.05）.The expression of HIF-1α protein was positively correlated to that of VEGF165 protein（P0.05）.Conclusion The high expression of HIF-1 and VEGF165 protein in gastric cancer is closely related to the carcinogenesis,development and lymph node metastasis of gastric caner.Combined detection of HIF-1 and VEGF165 is helpful to the evaluation of biological behaviour of gastric carcinoma.

关 键 词：胃癌 缺氧诱导因子1Α 血管内皮生长因子165 

分 类 号：R735[医药卫生—肿瘤]