牙周机械治疗对2型糖尿病患者牙周健康及龈沟液白介素6水平的影响  

Effect of periodontal mechanical therapy on periodontal health and interleukin-6 levels in gingival crevicular fluid in type 2 diabetic patients with chronic periodontitis

作　　者：谭佳玮[1] 项立新[1] 刘丽[2] 

机构地区：[1]浙江医院口腔科,杭州310013 [2]浙江大学医学院附属口腔医院修复科

出　　处：《中华老年医学杂志》2011年第6期503-505,共3页Chinese Journal of Geriatrics

摘　　要：目的评价定期龈上洁治和龈下刮治对2型糖尿病患者牙周健康及龈沟液白介素6水平的影响。方法采用随机、对照、盲法设计，将37例2型糖尿病伴牙周炎患者分为基础治疗组（牙周基础治疗）13例、龈上洁治组（龈上洁治）11例及空白对照组13例，比较其治疗后6周、3个月和6个月时临床指标包括探诊深度（PD），附着丧失（AL），改良出血指数（mBI），菌斑指数（PLI）、龈沟液（GCF）量及龈沟液IL6水平的变化。结果基础治疗组各项指标在各时间点均较基线显著降低（P〈0．05），龈上洁治组呈现下降趋势，其中3个月时PD减少有统计学意义（Δ=0．36mm，P〈0．05）。基础治疗组、龈上洁治组6个月时GCF减少量显著高于对照组增加（0．96μl〉0．03μl mm〉-0．02μl，P〈0．05）。结论定期牙周机械治疗可改善糖尿病患者牙周健康及龈沟液IL6水平。Objective To evaluate the effectiveness of periodontal mechanical therapy on periodontal health and interleukin-6 （IL-6） levels in gingival crevicular fluid （GCF） in type 2 diabetic patients with chronic periodontitis. Methods GCF samples were obtained with filter papers in first molar sites from 37 type 2 diabetic patients with chronic periodontitis. The randomized controlled and blinded clinical trial with a duration of six months was designed to compare effects between three groups of professional mechanical tooth cleaning （PMTC）, i.e. coronal scaling （groupⅡ ） with periodontal initial therapy （group Ⅰ ） and without clinical therapy （control group）. The clinical periodontal index such as probing depth （PD）, attachment loss （AL）, modified bleeding index （mBI） and bacteria plaque index （PLI） were obtained with a Williams type periodontal probe. Laboratory examination including GCF volume, concentrations and total amounts of IL-6 in GCF were detected with EI.ISA method. Results Significantly decreasing trends of PD, AL, mBI, GCF volume and total amounts of IL-6 were observed in group Ⅰ in all test period. The group Ⅱ had a significant reduction of PD at the third month as compared with baseline （Δ = 0.36 ram, P〈0.05）, and the other figures showed descending trends but didnft present statistical significances. At the end of study, the group Ⅰ and Ⅱ had significant reductions of GCF volume compared with increases of control group （0.96μl〉0.03μlmm 〉 -- 0. 20μl, P〈0.05）. Conclusions The sequential periodontal supra and sub- gingival scaling has definitive effects on periodontal health improvement and on reducing the IL-6 level in GCF in type 2 diabetic patients.

关 键 词：糖尿病 2型 牙科刮治术 牙龈缝液 

分 类 号：R781.4[医药卫生—口腔医学]