青年乳腺癌50例保乳治疗分析  

Analysis of 50 young patients of breast cancer after conserving surgery

作　　者：王斌[1] 郭雪[1] 魏丽娟[1] 方志沂[1] 

机构地区：[1]乳腺癌防治教育部重点实验室天津市肿瘤防治重点实验室天津医科大学附属肿瘤医院乳腺二科,天津300060

出　　处：《实用肿瘤杂志》2011年第3期244-247,共4页Journal of Practical Oncology

摘　　要：目的探讨35岁以下乳腺癌保乳治疗临床特点及预后。方法对50例≤35岁的乳腺癌患者的临床病例资料进行分析。全部患者均行保乳术,即局部切除或者象限切除加腋窝淋巴结清扫术。结果 50例中位随访时间11月,30岁以下患者占40.0%;肿瘤最大径:≤2 cm占48.0%,>2 cm占52.0%;淋巴结无转移占80.0%,转移者占20.0%;ER/PR(+)占70.0%,ER、PR均为阴性占30%,两组10年无瘤生存率分别为94.3%和80.0%,差异有统计学意义(P=0.041);本组患者5年累计生存率为92.0%,10年累计生存率为86.0%。结论青年乳腺癌患者保乳术后常规需要化疗、放疗,ER、PR阳性患者需要内分泌治疗。ER/PR(+)患者较ER、PR(-)患者预后好。Objective To analyze the characteristics and the prognosis of breast cancer patients aged ≤ 35 years. Methods During April 1994 and December 2005, there were 50 breast cancer patients aged ≤35 years treated with conserving surgery in the Hospital of Tianjin Medical University. All of these patients underwent breast conserving surgery with axillaries dissection. Results The median follow-up was 11 months for 50 patients. The percentage of patients aged ≤30 years was 40.0% ;the percentage of tumor size ≤ 2 em was 48.0%, and 〉 2 cm 52.0% ; the percentage of the non-lymph node-metastasis was 80.0%, and the lymph node metastasis 20.0% ; the percentage of ER/PR（ ＋ ） was 70.0%, and both of ER and PR （ - ） 30.0%. The 10-year DFS （ disease free survival ） rates of E R/PR （ ＋ ） and ER and PR （ - ） were 94.3 % and 80.0% （ P = 0.041 ） ;the 5-year and 10-year OS （ overall survival） rates of the patients were 92. 0% and 86. 0%. Conclusions For young breast cancer patients treated with conserving surgery, the chemotherapy and radiotherapy are necessary;for ER/PR（ ＋ ） patients,endocrine therapy is necessary. The prognosis of ER/PR（ ＋ ）is better than ER and PR（ - ） patients.

关 键 词：乳腺肿瘤/外科学 年龄因素 淋巴结切除术 药物疗法 放射疗法 回顾性研究 

分 类 号：R737.9[医药卫生—肿瘤]