肾细胞癌的微卫星不稳定性研究  

Microsatellite instability in renal cell carcinoma

作　　者：唐东起[1] 俞莉章[1] 张爱民 刘漓波[1] 丁义[1] 郭应禄[1] 

机构地区：[1]北京医科大学第一医院泌尿外科北京医科大学泌尿外科研究所,100034 [2]山东东营胜利石油管理中心医院

出　　处：《中华泌尿外科杂志》1999年第12期715-718,共4页Chinese Journal of Urology

摘　　要：目的　探讨微卫星不稳定性在肾细胞癌发生发展中的作用及其与临床病理指标的关系。　方法　应用ＰＣＲ 方法检测了３４ 例新鲜肾细胞癌标本中不同染色体上的１５ 个微卫星位点。　结果　３４ 例肾癌中有１５ 例（４４％ ）表现为微卫星不稳定性，并多见于晚期肿瘤（Ⅲ～Ⅳ期） 。　结论　微卫星不稳定性较广泛地存在于肾细胞癌中，可能与肿瘤发展相关。Objective To demonstrate whether microsatellite instability is involved in the development of renal cell carcinoma and its relations to the clinicopathological parameters. Methods A PCR based microsatellite instability assay was carried out using 15 microsatellite loci located on different chromosomes.Thirty four freshly frozen samples were examined. Results Microsatellite instabilities were recognized in 15 out of 34(44%) tumor specimens and were more common in advanced cancer (stage Ⅲ～Ⅳ).No relations were found among microsatellite instability and other clinicopathological factors. Conclusions Microsatellite instability was importantly involved in human renal cell carcinoma and it might be associated with the development of this disease.

关 键 词：肾肿瘤 微卫星不稳定性 肾细胞癌 

分 类 号：R737.11[医药卫生—肿瘤]