OCT对7～18岁近视黄斑参数研究  

Evaluating the factors associated with variability in OCT characteristics of the macula in myopic juvenile

作　　者：陈伟[1] 傅培[1] 伍友春[1] 陶然[1] 刘颜[1] 杨琦[1] 王豫桂[1] 

机构地区：[1]北京大学深圳医院眼科,深圳518036

出　　处：《中国实用眼科杂志》2011年第6期569-573,共5页Chinese Journal of Practical Ophthalmology

基　　金：2010广东省深圳市科技计划项目（201003065）

摘　　要：目的探讨近视青少年黄斑厚度和黄斑容积的变异程度与等效球镜、眼轴长度、性别、年龄、及眼别的关系。方法横断面调查研究。应用Stratus相干光断层扫描（OCT）仪的黄斑快速扫描程序用直径为6mm的相邻30。的6条扫描线，测量154例（154只眼）7～18岁近视青少年的黄斑中心小凹、中心区和旁中心凹内、外环（直径分别为1、3、6mm）的颞、上、鼻、下各个区域的厚度和容积，并用A超测定眼轴长度。各影响因素与黄斑各区域的厚度和容积分别进行双变量直线回归分析。结果黄斑旁中心凹上方和鼻侧较下方和颞侧厚。黄斑中心凹最薄处厚度、黄斑中心区厚度和容积与等效球镜、眼轴长度、性别、年龄、及眼别均无关（P〉O．05）；黄斑区总容积与等效球镜度数呈正相关（r=0．273，P=0．001），与眼轴长度呈负相关（r=0．285，P=0．001）；内环和外环各方位厚度及容积与等效球镜均呈正相关（P〈0．05）；眼轴长度与内环下方和外环各方位厚度和容积呈负相关（P〈0．05）；年龄与内环鼻、颞侧、外环鼻侧厚度和容积呈正相关（P〈0．05）；性别与外环下方厚度和容积呈负相关（P〈0．05）；眼别与黄斑各区域厚度和容积均无关（P〉0．05）。结论随着近视程度和眼轴长度的增加，青少年黄斑部变薄的区域在旁中心凹区而不是中心区。在评价青少年黄斑厚度和黄斑容积时，需考虑其近视程度、眼轴长度、年龄及性别的影响。Objective To evaluate the associations between macular thickness and volume, assessed by optic coherence tomography （OCT）, with spherical equivalent （SE）, axial length （AL）, gender, age, eye in myopic juvenile. Methods Cross-sectional observational study. One hundred and fifty-four juvenile （age range, 7-18 years） underwent ophthalmic examination. Fast macular scans were performed by Stratus OCT with six 6-mm lines （oriented 30° apart） in a radial spokelike pattern on one randomly selected eye of each subject. Average macular thickness and macular volume was provided for each of the nine regions with outer radii for the central, inner, and outer macular regions being 1, 3 and 6ram, respectively. AL was respectively measured by A-ultrasound. The effects of several factors （SE, AL, gender, age, and eye） on macular thickness and volume were investigated in univariate analyses. Results The retina was thicker at the superior and nasal parafovea compared to the inferior or temporal parafovea. The mean minimum retinal thickness （at the foveola）, the central macular thickness and volume had no significant relationship between SE, AL, gender, age and eye （P 〉0. 05）. The total macular volume showed direct linear correlation with SE （r =0.273, P =0.001）, and inverse linear correlation with AL （r =0.285, P =0.001）. There was significant direct linear correlation between SE and the thickness and volume of inner and outer macula （P 〈0.05）. AL showed inverse linear correlation with the thickness and volume of inferior inner macula and outer macula （P 〈0.05）. Age showed direct linear correlation between the thickness and volume of nasal inner macula, temporal inner macula, nasal outer macula （P 〈0.05）. There was significant inverse linear correlation between the thickness and volume of inferior outer macula and gender （P〈0.05）. Macula thickness and volume was not significantly related to the laterality.Conclusions As the AL and the myopic degree of eye increase,

关 键 词：光学相干断层扫描 黄斑厚度 黄斑容积 近视 等效球镜 眼轴长度 

分 类 号：R770.4[医药卫生—眼科]