ATRA耐药基因HA117相关蛋白在肺癌和乳腺癌组织中的表达特点及临床意义  

Expression features of ATRA resistance gene HA117 related protein in lung and breast neoplasms and its clinical significance

作　　者：牟廷刚[1] 金先庆[1] 赵利华[1] 丁雄辉[1] 陈建飞[1] 孙艳辉[1] 李昆昆[1] 王士奇[1] 

机构地区：[1]重庆医科大学附属儿童医院普外科,400014

出　　处：《重庆医学》2011年第16期1563-1565,F0003,共4页Chongqing medicine

基　　金：国家自然科学基金资助项目(30471985)

摘　　要：目的探讨全反式维甲酸(ATRA)耐药基因HA117相关蛋白在肺癌和乳腺癌组织中的表达特点及临床意义。方法随机选择23例肺癌组织和21例乳腺癌组织作为实验组,9例非癌肺组织和11例非癌乳腺组织作为对照组,应用免疫组化S-P法检测HA117相关蛋白在上述组织切片中的表达,并结合其临床资料进行回顾性分析。结果 HA117相关蛋白在肺癌组织、乳腺癌组织、非癌肺组织及非癌乳腺组织中的阳性表达率分别为60.9%(14/23)、57.1%(12/21)、11.1%(1/9)及0.0%(0/11)。HA117相关蛋白在肺癌和乳腺癌组织中的阳性表达明显高于非癌组织(P<0.05)。HA117相关蛋白的表达水平与肺癌及乳腺癌患者的年龄、肿瘤分级、病理分型、淋巴结转移及有无术前化疗方面无明显相关性(P>0.05)。结论 HA117相关蛋白在肺癌和乳腺癌的高表达提示二者对ATRA具有较强的耐药性。Objective To explore the expression features of all trans retinotic acid（ATRA） resistance gene HA117 related protein in lung and breast neoplasm and its clinical significance.Methods 23 specimens of lung neoplasm and 21 specimens of breast neoplasm were randomly selected as experimental group,while 9 and 11 specimens of non-cancerous tissue of lung and breast as control group.Streptavidin-peroxidase immunohistochemistry staining method was employed to detect the expression of HA117 related protein in all specimens above and retrospective analysis was conducted combining their clinical data.Results The positive expression rates of HA117 related protein in lung neoplasm,breast neoplasm,non-cancerous tissue of lung and breast were 60.9%（14/23）,57.1%（12/21）,11.1%（1/9） and 0.0%（0/11）,respectively.The expression levels of HA117 related protein in lung and breast neoplasm were obviously higher than those in non-cancerous tissue（P0.05）,which showed no significant correlation with age of patients,tumor grades,pathological types,lymph node metastasis and with or without preoperative chemotherapy（P0.05）.Conclusion High levels of HA117 related protein expression in lung and breast neoplasm tissue indicate a strong resistance to ATRA exited in these two kind of cancer.

关 键 词：多药耐药相关蛋白类 基因 HA117 肺肿瘤 乳腺肿瘤 维甲酸 

分 类 号：R734.2[医药卫生—肿瘤] R737.9[医药卫生—临床医学]