谷氨酰胺治疗危重症感染合并胃肠功能障碍患者60例临床疗效观察  

CLINICAL OBSERVATION OF GLUTAMINE TREATMENT IN 60 PATIENTS WITH SEVERE GASTROINTESTINAL DYSFUNCTION

作　　者：贾民[1] 吴莉[2] 于永福[1] 樊锦春[2] 

机构地区：[1]新疆医科大学第五附属医院,乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院

出　　处：《现代预防医学》2011年第13期2620-2621,2623,共3页Modern Preventive Medicine

摘　　要：[目的]观察药理剂量的谷氨酰胺治疗危重症感染合并胃肠功能障碍患者的胃肠功能的评分及临床疗效。[方法]选择60例并发胃肠道功能障碍的危重症感染患者,随机分为治疗组(A组)和对照组(B组),A组采用针对原发病的常规治疗和脏器功能的支持治疗,同时给予药理剂量谷氨酰胺,B组仅给予针对原发病的常规治疗和脏器功能的支持治疗,比较两组治疗后胃肠功能评分及临床疗效。[结果]治疗组30例,显效9例,有效16例,无效5例;对照组30例,显效5例,有效11例,无效14例。胃肠功能评分比较,治疗组显著优于对照组,差异具有统计学意义(t=2.3017,P﹤0.05)。临床疗效比较,治疗组有效率(83.33)显著高于对照组(53.34),差异有统计学意义(χ2=6.3319,P=0.0422)。[结论]采用药理剂量的谷氨酰胺为主的综合治疗措施,治疗合并胃肠功能障碍的危重症感染患者,其胃肠功能评分及临床疗效有明显的改善。[Objective]To detect the gastrointestinal function scores and clinical effects of therapeutic Glutamine in 60 patients with severe gastrointestinal dysfunction.[Methods]We selected 60 patients with severe gastrointestinal dysfunction,who were randomly divided into two groups（A and B）.Group A was treated with therapeutic glutamine,conventional methods for primary disease and organ function support,while Group B was treated just with conventional methods for primary disease and organ function support.[Results]30 cases in Group A were treated,in which 9 cases were cured,16 showed effect,and 5 were ineffective,while in group B,5 cases were cured,11 cases showed effect and the left 14 cases had no effect.Both gastrointestinal function score and clinical effect in Group A were significantly higher than those in Group B,the differences were statistically significant（t = 2.301 7,P﹤0.05,χ2 = 6.331 9,P = 0.042 2）.[Conclusion]Glutamine treatment for gastrointestinal dysfunction in severe patients can improve gastrointestinal function and clinical effect of conventional treatment.

关 键 词：谷氨酰胺 危重症感染 胃肠功能障碍 

分 类 号：R57[医药卫生—消化系统]