薏米黄酒对机体免疫及肠道功能的调节作用研究  

Effects of Yellow Wine with Seeds of Job's Tears on Immunity and Intestinal Functions in Mice

作　　者：李珊[1] 吴海[1] 申可佳[1] 蔡光先[1] 谭周进[1] 蔡锐[1] 李迎秋[1] 

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《现代生物医学进展》2011年第12期2251-2253,2257,共4页Progress in Modern Biomedicine

基　　金：湖南省重点项目(2010SK2002);湖南新化县蚩尤酒厂科研资助

摘　　要：目的:考察薏米黄酒对机体免疫和肠道功能的调节作用。方法:将ICR小鼠随机分为3组:对照组、模型组和给药组。首先对模型组和给药组注射环磷酰胺造模,0.15 ml/d/只,连续3d,第4d开始对照组和模型组灌胃生理盐水0.3 ml/d/只,给药组灌胃薏米黄酒0.3 ml/d/只,连续灌胃14d。第1、4、18d对各组小鼠称重;第18d处死小鼠解剖取脾脏、胸腺称重并计算脏器系数;取肠道内容物做肠道微生物培养。结果:薏米黄酒与小鼠的体重变化无关;给药组脾脏系数高于对照组有统计学意义(P<0.05),胸腺系数高于对照组和模型组均有统计学意义(P<0.05);给药组细菌总数、大肠杆菌数和乳酸菌数高于模型组和对照组且有显著统计学意义(P<0.01),真菌数量低于模型组和对照组有统计学意义(P<0.05)。结论:该薏米黄酒对机体免疫和肠道功能有一定的调节作用。Objective：To observe the regulating function of Yellow Wine with the Seeds of Job＇s Tears on the immune and intestinal function.Methods：The ICR mice were randomly divided into 3 groups：the control group,the model group and the treated group.First,the model group and treatment group were injected with cyclophosphamide,then the control group and the model group were treated with normal saline only,the treated group were treated with Yellow Wine with the Seeds of Job＇s Tears.In the 18th day,The mice were killed,the weights of spleen and thymus were determined and the coefficients of viscera were calculated.In addition,the total number of intestinal microflora were measured.Results：The body weight of mice had nothing to do with Yellow Wine with the Seeds of Job＇s Tears.In the treated group the coefficient of spleen organ was higher than those in control group（P0.05）,and the coefficient of thymus organ was higher than those in control group and model group（P0.05）.The total number of bacteria colonies,E.coli and Lactobacillus in the intestinal were higher than those in control group and model group（P0.01）,and the number of fungi was lower than those in control group and model group（P0.05）.Conclusion：Yellow Wine with the Seeds of Job＇s Tears could enhance immune function and regulate intestinal function.

关 键 词：薏米黄酒 小鼠 免疫活性 肠道微生物 

分 类 号：TS262.4[轻工技术与工程—发酵工程]