HK-Ⅱ、TS和Ki-67在青年人结肠癌组织中的表达及其意义  

Expressions of HK-Ⅱ,TS and Ki-67 and Their Significance in Young Colon Cancer Patients

作　　者：冯青青[1] 刘红梅[2] 彭秋平[2] 柯传庆[2] 

机构地区：[1]解放军第94医院消化科,南昌330002 [2]解放军第94医院肿瘤科,南昌330002

出　　处：《肿瘤防治研究》2011年第6期663-665,共3页Cancer Research on Prevention and Treatment

摘　　要：目的检测己糖激酶-Ⅱ(HK-Ⅱ)、胸苷酸合成酶(TS)和Ki-67核抗原(Ki-67)在青年人结肠癌组织中的表达,并探讨其临床意义。方法采用免疫组织化学法检测78例青年人(≤40岁)结肠癌和75例随机抽取的同期收治的中老年人(>40岁)结肠癌组织中HK-Ⅱ、TS及Ki-67蛋白的表达。结果 HK-Ⅱ和TS在青年人组和中老年人组结肠癌组织中的阳性表达率分别为82.1%(64/78)和65.3%(49/75),69.2%(54/78)和52.0%(39/75),而Ki-67增殖指数分别为(59.1±3.0)%和(48.5±3.2)%。两组比较,以上三种蛋白的表达水平差异均有统计学意义(均P<0.01)。HK-Ⅱ、TS及Ki-67表达在青年人结肠癌肿瘤分化程度、分期之间的差异均有统计学意义(均P<0.05)。青年人结肠癌HK-Ⅱ表达与TS、Ki-67成正相关性。结论 HK-Ⅱ、TS和Ki-67阳性蛋白表达可作为青年人结肠癌的恶性指标。Objective To investigate the expressions of hexokinase type Ⅱ（HK-Ⅱ）,thymidylate synthase（TS） protein and Ki-67 nuclear antigen（Ki-67）,and to reveal their clinical significance in young patients with colon cancer.Methods The protein expressions of HK-Ⅱ,TS and Ki-67 in 78 patients（≤ 40 years） with colon cancer and 75 patients（ 40 years）,were detected by immunohistochemical technique with retrospective comparison.Results The positive expression rates of HK-Ⅱ and TS were 82.1%（64/78） and 65.3%（49/75）,69.2%（54/78） and 52.0%（39/75）,respectively,in young group and older group.Moreover,the Ki-67 proliferation indexes of both groups were（59.1±3.0）% and（48.5±3.2）%,respectively.Compared the young group with the older group,there were significant differences in the three positive expressions（both,P0.01）.Moreover,compared these positive expressions of HK-Ⅱ,TS and Ki-67 with those negative expressions in the young colon cancer patients,there were significant differences in cancer＇s differentiation and stage（both,P0.01）.The positive expression of HK-Ⅱ was consistent with the positive expressions of TS and Ki-67,respectively,in young patients with colon cancer.Conclusion The positive protein expressions of HK-Ⅱ,TS and Ki-67 may be malignant biomarkers.

关 键 词：结肠肿瘤 己糖激酶-Ⅱ 胸苷酸合成酶 KI-67核抗原 青年患者 

分 类 号：R735.35[医药卫生—肿瘤]