SFRP1和Wnt-1在宫颈鳞癌中的表达及意义  

Expression and Significance of SFRP1 and Wnt-1 in Cervical Squamous Cell Carcinoma

作　　者：王美红[1] 李兵 张式暖[1] 

机构地区：[1]潍坊医学院病理学教研室,山东潍坊261053 [2]潍坊市立医院病理科

出　　处：《肿瘤防治研究》2011年第6期679-681,共3页Cancer Research on Prevention and Treatment

摘　　要：目的探讨SFRP1和Wnt-1在宫颈鳞癌中的表达及意义。方法采用免疫组织化学SP法检测SFRP1和Wnt-1蛋白在20例宫颈正常鳞状上皮、70例宫颈上皮内瘤变(cervical intraepithelial neo-plasia,CIN)及50例宫颈鳞癌中的表达。结果 (1)宫颈正常鳞状上皮、CINⅠ、CINⅡ/Ⅲ及宫颈鳞癌组织中,SFRP1阳性表达率分别是100%、73.5%、67.5%、34%(χ2=30.85,P<0.005);Wnt-1的阳性表达率分别是25%、60%、82.5%、98%(χ2=45.57,P<0.005)。(2)SFRP1和Wnt-1在宫颈鳞癌中的表达无相关性(P>0.05)。(3)在宫颈鳞癌组织中,两者表达与患者的年龄、肿瘤大小、临床分期无相关性(P均>0.05),而在不同组织分化程度间表达差异有统计学意义(P均<0.05)。结论 SFRP1和Wnt-1参与了宫颈鳞状上皮的恶性转化过程,在由CIN发展到宫颈鳞癌的过程中起了促进作用。Objective To explore the expression and significance of SFRP1 and Wnt-1 in cervical squamous cell carcinoma.Methods SFRP1 and Wnt-1 were detected by immunohistochemistry（SP） in 20 cases of normal cervical squamous epithelium,30 cases of CINⅠ,40 cases of CINⅡ/Ⅲ and 50 cases of cervical squamous cell carcinoma.Results（1）In normal cervical squamous epithelium,CINⅠ,CINⅡ/Ⅲ and cervical squamous cell carcinoma,the positive expression rate of SFRP1 were 100%,73.5%,67.5% and 34% respectively.The positive expression rate of Wnt-1 were 25%,60%,82.5% and 98% respectively.There was significantly different among four groups（P0.05）.（2）There was no correlation between SFRP1 and Wnt-1 in cervical squamous cell carcinoma.（3）In cervical squamous cell carcinoma group,there was no significant difference for SFRP1 and Wnt-1 expression in different age patient groups,and there was no difference among different tumor size,and clinical stages.However,there was significant difference among different pathological grades（P0.05）.Conclusion SFRP1 and Wnt-1 were related to the process of cancerating of cervical squamous epithelium,which maybe play important roles in the development from cervical intraepithelium neoplasis to invasive cervical squamous cell carcinoma.

关 键 词：宫颈肿瘤 宫颈上皮内瘤变 分泌型卷曲相关蛋白1 Wnt-1蛋白 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]