脊髓损伤动物模型的运动功能评价  

Motor function evaluation of animal models for spinal cord injury

作　　者：顾兵[1] 金建波[2] 李华南[2] 张国福[2] 

机构地区：[1]江西科技师范学院药学院,江西南昌330013 [2]江西中医学院药学院,江西南昌330006

出　　处：《中国药理学通报》2011年第7期893-897,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30960448);江西省教育厅科技资助项目(NoGJJ09546;GJJ11596)

摘　　要：不同的脊髓损伤动物模型复制出不同类型的解剖结构损伤以及相应的行为学改变。损伤后的运动功能评价既可直接衡量脊髓的再生、修复和神经功能的重建,也是开展神经保护药物药效学试验不可或缺的环节。该文就国内外已经建立的评价方法作系统综述,同时列举其在实验治疗学上的应用,指导研究者选用合适的评价方法。Different animal models of spinal cord injury duplicate different types of anatomical structure damage and corresponding behavioral changes.Evaluating motor function after injury can directly measure the regeneration and restoration of spinal cord and the reconstruction of neurological function.It is the integral part of pharmacodynamic trials for neuroprotective drugs as well.This review systematically describes the progress of evaluation methods,which have been established at home and abroad.Based upon the aforementioned evaluation method,some relevant applications in experimental therapeutics are simultaneously enumerated.All these information contributes to guiding the researchers to select appropriate evaluation method.

关 键 词：脊髓损伤 动物模型 运动功能 评价方法 BBB法 步态分析 

分 类 号：R-05[医药卫生] R3632-332