虫草头孢菌粉水提物抗实验性心律失常作用的研究  

Experimental studies on antiarrhythmic effect of cordyceps cephalosporium mycelia extracts

作　　者：姚红伊[1] 沈礼[2] 林国华[2] 沈岳良[3] 王如伟 谢强敏[1] 颜小锋[1] 

机构地区：[1]浙江大学医学院附属第二医院药剂科,浙江杭州310009 [2]杭州师范大学基础医学部,浙江杭州310018 [3]浙江大学医学院病理学与病理生理学系,浙江杭州310058 [4]浙江康恩贝制药股份有限公司,浙江杭州310052

出　　处：《中国药理学通报》2011年第7期1015-1018,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30772581);浙江省科技厅重点科技攻关项目(No2007C23022)

摘　　要：目的观察采用专利改良技术获得的虫草头孢菌粉(Cordyceps Cephalosporium Mycelia,CCM)提取物对氯仿、乌头碱和缺血/再灌诱发的心律失常的作用。方法专利改良技术获得的CCM提取物主要化合物分别为:腺苷38.1%、尿苷35%和胸苷13%。采用氯仿诱导小鼠心律失常,静脉注射乌头碱和冠脉结扎法诱导大鼠心律失常,均术前给予CCM提取物,记录并分析心电图曲线。结果 CCM提取物能剂量依赖性地降低氯仿诱发的小鼠室颤发生率,延长乌头碱诱发各种室性心律失常出现的时间,降低缺血复灌性心律失常评分。结论改良技术获得的CCM提取物有效部位可对抗氯仿、乌头碱和缺血诱导的实验性心律失常。Aim To investigate the antiarrhythmic effect of Cordyceps Cephalosporium Mycelia（CCM） extracts.Methods The conventional antiarrhythmic methods were used.Arrhythmia was induced by chloroform in mice.The intravenous injection of aconitine and coronary artery ligation method were performed to induce arrhythmia in rat model,which were given CCM extraction in preoperation.Electrocardiogram currve was recorded and analysed.Results Administration of CCM extraction reduced the occurrence of ventricular fibrillation induced by chloroform in a dose-dependent manner in mice.CCM significantly prolonged the onset of arrhythmia induced by aconitine in rats.Compared with control,arrhythmia score was lower in ischemia/reperfusion rats pretreated with CCM extracts.Conclusion CCM extracts has obvious protective effects on chloroform,conitine-and ischemia-reperfusion induced arrhythmia.

关 键 词：虫草头孢菌粉 心律失常 氯仿 乌头碱 缺血 再灌注损伤 

分 类 号：R-332[医药卫生] R282.71