踝臂脉搏波传导速度及踝肱指数与缺血性脑卒中的相关性研究  

The Study on the Correlation of Pulse Wave Velocity and Ankle-brachial Index to Ischemic Stroke in Patients

作　　者：李慧[1] 王晗[1] 王玉才[2] 饶莉[1] 

机构地区：[1]四川大学华西医院心血管内科,成都610041 [2]四川大学华西医院神经内科,成都610041

出　　处：《生物医学工程学杂志》2011年第3期559-562,共4页Journal of Biomedical Engineering

基　　金："十一五"国家科技支撑计划项目资助(2007BAI05B01)

摘　　要：本研究对97例缺血性脑卒中组(病例组)患者及同期住院的非缺血性脑卒中组(对照组)患者行踝臂脉搏波传导速度(baPWV)及踝肱指数(ABI)测量及临床资料回顾性分析,探讨baPWV、ABI与缺血性脑卒中及其危险因素的关系,并对病例组患者按磁共振脑血管造影检查及颈动脉彩色多普勒超声结果分组,分析baPWV、ABI与颅内动脉及颈总动脉硬化程度的关系。结果示病例组与对照组之间高血压、糖尿病、baPWV及ABI异常有统计学意义,在所有危险因素中baPWV是缺血性脑卒中最敏感的危险因素,ABI、糖尿病是较敏感因素。病例组患者颈总动脉内中膜厚度(IMT)与baPWV正相关(γ=0.215,P=0.048),与ABI无明显相关性,病例组患者颅内动脉狭窄程度与baPWV无相关,与ABI呈负相关(γ=-0.237,P<0.05)。说明baPWV、ABI是缺血性脑卒中发生的独立危险因素baPWV、ABI可用于评估缺血性脑卒中的患病危险。We measured the Ankle-brachial index（ABI） and brachial-ankle pulse wave velocity（baPWV） and ABI in 97 ischemic stroke patients and 93 control subjects to investigate the relationship between baPWV,ABI and risk factors of ischemic stroke.The stroke patients were grouped according to the results of MRA and Carotid artery color Doppler ultrasound.The correlation of baPWV and ABI to the arteriosclerosis was discussed.There was a significant difference in the patients with hypertension,diabetes mellitus,baPWV and ABI between ischemic stroke patients and control subjects.BaPWV was the most sensitive risk factor for ischemic stroke.ABI and diabetes mellitus were the relatively sensitive risk factors for ischemic stroke.BaPWV were found to have a positive correlation with common carotid arteriosclerosis（γ=0.215,P=0.048）,while ABI had a negative correlation with intracranial arteriosclerosis（γ=-0.237,P0.05）.BaPWV and ABI may closely relate to severity of ischemic stroke.Simple measurements of baPWV and ABI in patients could be a useful tool for evaluating the risk of ischemic stroke.

关 键 词：踝臂脉搏波传导速度 踝肱指数 缺血性脑卒中 危险因素 动脉硬化 

分 类 号：R743.3[医药卫生—神经病学与精神病学]