基于多目标评价模型的SMC4L1基因的乳腺癌易感性分析  

Analysis for Susceptibility of Breast Cancer Due to Gene SMC4L1 Based on a Multi-criteria Evaluation Model

作　　者：徐超[1] 蒋艳[1] 

机构地区：[1]上海理工大学系统科学与工程系,上海200093

出　　处：《生物医学工程学杂志》2011年第3期582-586,共5页Journal of Biomedical Engineering

基　　金：上海市重点学科(第三期)建设项目资助(S30501)

摘　　要：本文通过引入基于多目标评价的乳腺癌易感基因评价模型,运用加权和法与逼近理想解排序(TOPSIS)法计算候选基因与乳腺癌易感性之间关系强弱的评价值,对一些与已知乳腺癌易感基因有关联的候选基因进行乳腺癌易感性分析。分析表明:该评价模型给出了反映候选基因与乳腺癌易感性正相关性的评价值,能够准确地反映候选基因与乳腺癌易感性之间的关系。在已有的研究中被认为是或很可能是乳腺癌易感基因的几个基因,都处于该评价模型所给出的评价结果值靠前的位置。在此基础上,本文着重从多个角度对排名第三的基因SMC4L1的乳腺癌易感性进行详细分析,确认SMC4L1是一个潜在的乳腺癌易感基因。因此,SMC4L1基因以及评价结果中靠前的基因都值得研究人员优先深入研究。The recent literature has proposed a multi-criteria evaluation model for breast cancer susceptibility.In this paper we employ the model to analyze the breast cancer susceptibility of several candidate genes having various relations with known breast cancer genes.Based on the model,we employed weight sum and TOPSIS methods to calculate the quantitative relations between candidate genes and breast cancer susceptibility.After the calculation,two ranking evaluation lists of alternatives were resulted from the two methods.The results generated with the two different methods were remarkably similar,while the top 7 were exactly identical.So the top 7 genes were analyzed,and the result from multi-criteria model was consistent with the previous research.A search of the literature using PubMed demonstrates CDC2 gene ranked first is researched frequently.Furthermore,TopBP1 gene ranked second and HMMR gene ranked 6th are identified as susceptibility genes for breast cancer by references in the literature.This multi-objective evaluation model can accurately represent the complex relationship between candidate genes and breast cancer susceptibility.Then this paper focuses on SMC4L1 gene ranked third.The analysis from various aspects indicates that SMC4L1 is potential to be a susceptibility gene for breast cancer.It＇s worthwhile to research on SMC4L1 and other top genes in result prior to and afterwards.

关 键 词：乳腺癌易感性 SMC4L1基因 多目标评价模型 加权和法 逼近理想解排序法 

分 类 号：R737.9[医药卫生—肿瘤]