COMT基因多态性rs4818与精神分裂症及迟发性运动障碍的关联性分析  

Analysis on association between COMT gene rs4818 polymorphism and schizophrenia and tardive dyskinesia

作　　者：孙颖[1] 于跃[2] 张逸远[2] 刘姗姗[1] 赵刚[3] 刘颖[4] 王宝贵[1] 孙世龙[3] 

机构地区：[1]吉林大学公共卫生学院营养与食品卫生学教研室,吉林长春130021 [2]吉林大学白求恩医学院 [3]吉林大学公共卫生学院卫生部放射生物学重点实验室,吉林长春130021 [4]吉林大学公共卫生学院卫生毒理学教研室,吉林长春130021

出　　处：《吉林大学学报（医学版）》2011年第3期491-494,共4页Journal of Jilin University：Medicine Edition

基　　金：吉林大学基本科研业务费项目资助课题(200903117);国家自然科学基金青年基金项目资助课题(30700672);吉林省科技厅科研基金资助课题(201105020)

摘　　要：目的:检测中国北方汉族人群中精神分裂症患者COMT基因多态性rs4818基因型及等位基因频数分布,探讨其与精神分裂症及迟发性运动障碍(TD)发生的关系。方法:以273例并发TD的精神分裂症患者(TD组)、114例未发生TD的精神分裂症患者(非TD组)和286例正常健康人群(正常对照组)为研究对象,采用Taqman探针方法检测COMT基因多态rs4818基因型和等位基因频数的分布。结果:与正常对照组比较,精神分裂症患者rs4818 G/G基因型频数分布差异有统计学意义(χ2=6.186,df=3,P=0.045);与正常对照组比较,TD组患者rs4818 G/G基因型频数分布差异有统计学意义(χ2=6.081,df=3,P=0.048);非TD组患者与正常对照组比较,G等位基因频数分布差异有统计学意义(χ2=4.049,df=2,P=0.044);TD组与非TD组比较,rs4818基因型及等位基因频数分布差异无统计学意义(χ2=0.634,df=2,P=0.426;χ2=0.848,df=3,P=0.654)。结论:COMT基因多态性与精神分裂症的发生有关联,但与精神分裂症TD的发生无关联性。Objective To detect the distribution of genotype and allele of COMT gene polymorphism rs4818 in Han Chinese patients with schizophrenia in North China and investigate the possible association between COMT gene polymorphism and schizophrenia and tardive dyskinesia（TD）.Methods The distribution of genotype and allele of COMT gene polymorphism rs4818 was detected in 273 schizophrenic patients with TD,114 schizophrenic patients without TD and 286 normal controls by Taqman assays.Results There were significant differences of the frequency of rs4818 G/G between schizophrenia and control groups（χ2=6.186,df=3,P=0.045）and between TD and control groups（χ2=6.081,df=3,P=0.048）.The frequency of G allele in non-TD group was lower than that in control group（χ2=4.049,df=2,P=0.044）.There were no significant differences of the frequencies of rs4818 genotype and allele between TD and non-TD group（χ2=0.634,df=2,P=0.426;χ2=0.848,df=3,P=0.654）.Conclusion The COMT rs4818 polymorphism may be associated with schizophrenia but not TD in the Han Chinese population.

关 键 词：儿茶酚胺氧位甲基转移酶基因 基因多态性 精神分裂症 迟发性运动障碍 

分 类 号：R749.3[医药卫生—神经病学与精神病学]