SDF-1与VEGF在胶质瘤表达中的关系及意义  

The Expression Significance and Relationship Study of SDF-1 and VEGF in Glioma

作　　者：王宏宇[1] 丁鹏[1] 李玉[1] 龙江[1] 陆斌[1] 宋晓斌[1] 

机构地区：[1]昆明医学院第一附属医院神经外科,云南昆明650032

出　　处：《昆明医学院学报》2011年第5期36-39,共4页Journal of Kunming Medical College

基　　金：云南省科技计划资助项目(2010CD157)

摘　　要：目的检测基质细胞衍化因子SDF-1和血管内皮生长因子VEGF在神经胶质瘤中的表达,探讨二者在胶质瘤中的表达关系.方法手术取胶质瘤标本32例,Ⅰ～Ⅳ级各8例,以免疫组化法行胶质瘤标本SDF-1和VEGF染色,分别检测SDF-1和VEGF在不同分级胶质瘤中的表达.结果 SDF-1和VEGF在胶质瘤标本中的表达与分级密切相关,SDF-1和VEGF表达的阳性率明显随级别增高而表达增强(P<0.05),且肿瘤中SDF-1和VEGF的表达呈正相关(P<0.05).结论 SDF-1和VEGF在胶质瘤发生发展中可能具有协同作用,在肿瘤进展中可能有一定促进作用,联合检测SDF-1和VEGF可能有助于判断胶质瘤的恶性程度.Objective To detect the expression of SDF-l and VEGF protein.and investigate their relationship and significance in glioma.Method We detected the expresion of SDF-l and VEGF in glioma by using IHC in 32 cases,8 cases in each level（I-IV）.Results The expression of SDF-1 and VEGF was correlated with tumor grade.Positive correlation between SDF-l and VEGF was found in glioma.Conclusions The expression of SDF-1 and VEGF may has synergetic effect and promote the occurrence and development of glioma.Combined determination of SDF-1 and VEGF may help to judge the malignant degree of glioma

关 键 词：胶质瘤 基质细胞衍生因子 血管内皮生长因子 免疫组化 

分 类 号：R739.41[医药卫生—肿瘤]