谷氨酰胺颗粒干预重度慢性乙型病毒性肝炎内毒素血症的临床疗效观察  

Observation of the effect of glutamine on endotoxemia in patients with severe chronic hepatitis B

作　　者：高勐[1] 杨建荣[2] 宋怀宇[3] 姜春华[3] 

机构地区：[1]广西中医学院第一临床学院,南宁530021 [2]广西壮族自治区人民医院肝胆腺体外科,南宁530021 [3]南宁市第四人民医院肝病科,广西530023

出　　处：《中国临床新医学》2011年第6期493-495,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西自然科学基金资助项目(编号:桂科回0639013);广西卫生厅重点科研课题(编号:桂卫重200810号)

摘　　要：目的观察谷氨酰胺颗粒干预重度慢性乙型病毒性肝炎内毒素血症的临床疗效。方法将60例重度慢性乙型病毒性肝炎内毒素血症患者随机分成对照组和治疗组,每组30例。对照组采用常规护肝、抗病毒治疗,而治疗组在对照组治疗方案的基础上加用谷氨酰胺颗粒10 g,3次/d,疗程为2周。观察治疗前后两组患者的血清内毒素、肝功能的变化以及治疗后的总有效率。结果治疗组总有效率(83.3%)优于对照组(50.0%),差异有统计学意义(P<0.01)。两组肝功能、血清内毒素较治疗前均有不同程度好转,治疗组与对照组比较差异有统计学意义(P<0.05或P<0.01)。结论谷氨酰胺颗粒治疗重度慢性乙型病毒性肝炎内毒素血症是一种有效的辅助治疗方法。Objective To study the clinical effect of glutamine on endotoxemia in patients with severe chronic hepatitis B. Methods Sixty patients with severe chronic hepatitis B were randomly divided into control group（n = 30） and treatment group（ n = 30）. The patients were given regular treatment, including hepatic proteetants and anti- virology therapy in control group. The patients were given extra glutamine 10 g Tid in addition to regular treatment in treatment group. The wbole treatment duration lasted two weeks. Endotoxin （ET）, liver function and the effective rate were compared between the two groups. Results The effective rate of the treatment group was 83.3% and that of the control group was 50. 0%, which were significant difference （ P 〈 0. 01 ）. The total tests of liver function, serum endotoxin level showed positive changes in both of two groups （P 〈 0. 05 or P 〈 0. 01 ）. Conclusion Adding glutamine to regular treatment is an effective adjuvant therapy for patients with severe chronic hepatitis B.

关 键 词：重度慢性乙型病毒性肝炎 谷氨酰胺颗粒 内毒素血症 肝功能 

分 类 号：R575.1[医药卫生—消化系统]